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Effects of porous tantalum on periprosthetic bone remodeling around metaphyseal filling femoral stem: a multicenter, prospective, randomized controlled study
Periprosthetic bone loss due to adaptive bone remodeling is an important unresolved issue in cementless total hip arthroplasty (THA). The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. W...
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Published in: | Scientific reports 2022-01, Vol.12 (1), p.914-9, Article 914 |
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creator | Motomura, Goro Mashima, Naohiko Imai, Hiroshi Sudo, Akihiro Hasegawa, Masahiro Yamada, Harumoto Morita, Mitsuhiro Mitsugi, Naoto Nakanishi, Ryosuke Nakashima, Yasuharu |
description | Periprosthetic bone loss due to adaptive bone remodeling is an important unresolved issue in cementless total hip arthroplasty (THA). The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. We conducted a multicenter randomized controlled study to determine if porous tantalum could reduce periprosthetic bone loss after THA. From October 2012 to September 2014, 118 patients (mean age, 61.5 years; 107 females and 11 males) were prospectively enrolled and were randomly allocated at a ratio of 1:1 to either a metaphyseal filling stem with a proximal porous tantalum coating (Trabecular Metal) or a conventional metaphyseal filling stem with fiber mesh coating (VerSys). Patients underwent dual-energy x-ray absorptiometry scans within 1 week after surgery (baseline) and at 6, 12, and 24 months after surgery to assess periprosthetic bone mineral density (BMD) in the 7 Gruen zones. In addition, the Japanese Orthopaedic Association hip score was assessed before surgery and at 6, 12, and 24 months after surgery. In the proximal periprosthetic region (zones 1 and 7), the Trabecular Metal group had significantly smaller reductions in BMD than the VerSys group throughout the study period. In the VerSys group, significant reductions in BMD compared to baseline were seen at each measurement point in all regions, except in zone 6 at 24 months. In the Trabecular Metal group, no significant reductions in BMD relative to baseline were seen in zones 1, 5, or 6 throughout the study period. Both groups demonstrated similar improvement in Japanese Orthopaedic Association hip scores over the study period. This study demonstrated that a proximally coated stem with porous tantalum has superior results over a conventional stem with titanium fiber mesh in terms of periprosthetic bone remodeling. |
doi_str_mv | 10.1038/s41598-022-04936-2 |
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The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. We conducted a multicenter randomized controlled study to determine if porous tantalum could reduce periprosthetic bone loss after THA. From October 2012 to September 2014, 118 patients (mean age, 61.5 years; 107 females and 11 males) were prospectively enrolled and were randomly allocated at a ratio of 1:1 to either a metaphyseal filling stem with a proximal porous tantalum coating (Trabecular Metal) or a conventional metaphyseal filling stem with fiber mesh coating (VerSys). Patients underwent dual-energy x-ray absorptiometry scans within 1 week after surgery (baseline) and at 6, 12, and 24 months after surgery to assess periprosthetic bone mineral density (BMD) in the 7 Gruen zones. In addition, the Japanese Orthopaedic Association hip score was assessed before surgery and at 6, 12, and 24 months after surgery. In the proximal periprosthetic region (zones 1 and 7), the Trabecular Metal group had significantly smaller reductions in BMD than the VerSys group throughout the study period. In the VerSys group, significant reductions in BMD compared to baseline were seen at each measurement point in all regions, except in zone 6 at 24 months. In the Trabecular Metal group, no significant reductions in BMD relative to baseline were seen in zones 1, 5, or 6 throughout the study period. Both groups demonstrated similar improvement in Japanese Orthopaedic Association hip scores over the study period. This study demonstrated that a proximally coated stem with porous tantalum has superior results over a conventional stem with titanium fiber mesh in terms of periprosthetic bone remodeling.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-022-04936-2</identifier><identifier>PMID: 35042918</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/2779/777 ; 692/4023/1671/63 ; Absorptiometry, Photon ; Aged ; Arthroplasty, Replacement, Hip - adverse effects ; Arthroplasty, Replacement, Hip - methods ; Bone Density ; Bone loss ; Bone mineral density ; Bone Remodeling ; Bone surgery ; Coatings ; Dual energy X-ray absorptiometry ; Female ; Femur ; Femur - diagnostic imaging ; Femur - surgery ; Hip ; Hip Prosthesis - adverse effects ; Humanities and Social Sciences ; Humans ; Male ; Middle Aged ; multidisciplinary ; Orthopedics ; Patients ; Porosity ; Prospective Studies ; Science ; Science (multidisciplinary) ; Surgery ; Surgical mesh ; Tantalum ; Tantalum - chemistry ; Titanium ; Total hip arthroplasty</subject><ispartof>Scientific reports, 2022-01, Vol.12 (1), p.914-9, Article 914</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-10df4e3663edbcde4e24a3f53d48aac3e7701f3f89539240a240c4d48c4c6a0c3</citedby><cites>FETCH-LOGICAL-c540t-10df4e3663edbcde4e24a3f53d48aac3e7701f3f89539240a240c4d48c4c6a0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2620906339/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2620906339?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35042918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motomura, Goro</creatorcontrib><creatorcontrib>Mashima, Naohiko</creatorcontrib><creatorcontrib>Imai, Hiroshi</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Yamada, Harumoto</creatorcontrib><creatorcontrib>Morita, Mitsuhiro</creatorcontrib><creatorcontrib>Mitsugi, Naoto</creatorcontrib><creatorcontrib>Nakanishi, Ryosuke</creatorcontrib><creatorcontrib>Nakashima, Yasuharu</creatorcontrib><title>Effects of porous tantalum on periprosthetic bone remodeling around metaphyseal filling femoral stem: a multicenter, prospective, randomized controlled study</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Periprosthetic bone loss due to adaptive bone remodeling is an important unresolved issue in cementless total hip arthroplasty (THA). The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. We conducted a multicenter randomized controlled study to determine if porous tantalum could reduce periprosthetic bone loss after THA. From October 2012 to September 2014, 118 patients (mean age, 61.5 years; 107 females and 11 males) were prospectively enrolled and were randomly allocated at a ratio of 1:1 to either a metaphyseal filling stem with a proximal porous tantalum coating (Trabecular Metal) or a conventional metaphyseal filling stem with fiber mesh coating (VerSys). Patients underwent dual-energy x-ray absorptiometry scans within 1 week after surgery (baseline) and at 6, 12, and 24 months after surgery to assess periprosthetic bone mineral density (BMD) in the 7 Gruen zones. In addition, the Japanese Orthopaedic Association hip score was assessed before surgery and at 6, 12, and 24 months after surgery. In the proximal periprosthetic region (zones 1 and 7), the Trabecular Metal group had significantly smaller reductions in BMD than the VerSys group throughout the study period. In the VerSys group, significant reductions in BMD compared to baseline were seen at each measurement point in all regions, except in zone 6 at 24 months. In the Trabecular Metal group, no significant reductions in BMD relative to baseline were seen in zones 1, 5, or 6 throughout the study period. Both groups demonstrated similar improvement in Japanese Orthopaedic Association hip scores over the study period. This study demonstrated that a proximally coated stem with porous tantalum has superior results over a conventional stem with titanium fiber mesh in terms of periprosthetic bone remodeling.</description><subject>692/308/2779/777</subject><subject>692/4023/1671/63</subject><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Bone Density</subject><subject>Bone loss</subject><subject>Bone mineral density</subject><subject>Bone Remodeling</subject><subject>Bone surgery</subject><subject>Coatings</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Female</subject><subject>Femur</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - surgery</subject><subject>Hip</subject><subject>Hip Prosthesis - adverse effects</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Porosity</subject><subject>Prospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Surgery</subject><subject>Surgical mesh</subject><subject>Tantalum</subject><subject>Tantalum - 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adverse effects</topic><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Bone Density</topic><topic>Bone loss</topic><topic>Bone mineral density</topic><topic>Bone Remodeling</topic><topic>Bone surgery</topic><topic>Coatings</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Female</topic><topic>Femur</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - surgery</topic><topic>Hip</topic><topic>Hip Prosthesis - adverse effects</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Porosity</topic><topic>Prospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Surgery</topic><topic>Surgical mesh</topic><topic>Tantalum</topic><topic>Tantalum - chemistry</topic><topic>Titanium</topic><topic>Total hip arthroplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motomura, Goro</creatorcontrib><creatorcontrib>Mashima, Naohiko</creatorcontrib><creatorcontrib>Imai, Hiroshi</creatorcontrib><creatorcontrib>Sudo, Akihiro</creatorcontrib><creatorcontrib>Hasegawa, Masahiro</creatorcontrib><creatorcontrib>Yamada, Harumoto</creatorcontrib><creatorcontrib>Morita, Mitsuhiro</creatorcontrib><creatorcontrib>Mitsugi, Naoto</creatorcontrib><creatorcontrib>Nakanishi, Ryosuke</creatorcontrib><creatorcontrib>Nakashima, Yasuharu</creatorcontrib><collection>Springer_OA刊</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>PHMC-Proquest健康医学期刊库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motomura, Goro</au><au>Mashima, Naohiko</au><au>Imai, Hiroshi</au><au>Sudo, Akihiro</au><au>Hasegawa, Masahiro</au><au>Yamada, Harumoto</au><au>Morita, Mitsuhiro</au><au>Mitsugi, Naoto</au><au>Nakanishi, Ryosuke</au><au>Nakashima, Yasuharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of porous tantalum on periprosthetic bone remodeling around metaphyseal filling femoral stem: a multicenter, prospective, randomized controlled study</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2022-01-18</date><risdate>2022</risdate><volume>12</volume><issue>1</issue><spage>914</spage><epage>9</epage><pages>914-9</pages><artnum>914</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Periprosthetic bone loss due to adaptive bone remodeling is an important unresolved issue in cementless total hip arthroplasty (THA). The use of porous tantalum on the proximal surface of the femoral stem is expected to decrease postoperative bone loss around the prosthesis through early fixation. We conducted a multicenter randomized controlled study to determine if porous tantalum could reduce periprosthetic bone loss after THA. From October 2012 to September 2014, 118 patients (mean age, 61.5 years; 107 females and 11 males) were prospectively enrolled and were randomly allocated at a ratio of 1:1 to either a metaphyseal filling stem with a proximal porous tantalum coating (Trabecular Metal) or a conventional metaphyseal filling stem with fiber mesh coating (VerSys). Patients underwent dual-energy x-ray absorptiometry scans within 1 week after surgery (baseline) and at 6, 12, and 24 months after surgery to assess periprosthetic bone mineral density (BMD) in the 7 Gruen zones. In addition, the Japanese Orthopaedic Association hip score was assessed before surgery and at 6, 12, and 24 months after surgery. In the proximal periprosthetic region (zones 1 and 7), the Trabecular Metal group had significantly smaller reductions in BMD than the VerSys group throughout the study period. In the VerSys group, significant reductions in BMD compared to baseline were seen at each measurement point in all regions, except in zone 6 at 24 months. In the Trabecular Metal group, no significant reductions in BMD relative to baseline were seen in zones 1, 5, or 6 throughout the study period. Both groups demonstrated similar improvement in Japanese Orthopaedic Association hip scores over the study period. This study demonstrated that a proximally coated stem with porous tantalum has superior results over a conventional stem with titanium fiber mesh in terms of periprosthetic bone remodeling.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35042918</pmid><doi>10.1038/s41598-022-04936-2</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 692/308/2779/777 692/4023/1671/63 Absorptiometry, Photon Aged Arthroplasty, Replacement, Hip - adverse effects Arthroplasty, Replacement, Hip - methods Bone Density Bone loss Bone mineral density Bone Remodeling Bone surgery Coatings Dual energy X-ray absorptiometry Female Femur Femur - diagnostic imaging Femur - surgery Hip Hip Prosthesis - adverse effects Humanities and Social Sciences Humans Male Middle Aged multidisciplinary Orthopedics Patients Porosity Prospective Studies Science Science (multidisciplinary) Surgery Surgical mesh Tantalum Tantalum - chemistry Titanium Total hip arthroplasty |
title | Effects of porous tantalum on periprosthetic bone remodeling around metaphyseal filling femoral stem: a multicenter, prospective, randomized controlled study |
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