Outcomes from intracerebral hemorrhage among patients pre-treated with statins

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved clinical outcomes after ischemic stroke and subarachnoid hemorrhage, but with an increased risk of incidental spontaneous intracerebral hemorrhage (ICH). We investigated whether the s...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2011-06, Vol.69 (3), p.452-454
Main Authors: Romero, Flávio Ramalho, Bertolini, Eduardo de Freitas, Veloso, Vanessa Nogueira, Venturini, Leandro, Figueiredo, Eberval G
Format: Article
Language:English
Subjects:
Aged
Cerebral Hemorrhage - drug therapy
Cerebral Hemorrhage - mortality
Disability Evaluation
Follow-Up Studies
Glasgow Outcome Scale
hemorragia cerebral
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
inibidores de hidroximetilglutaril-CoA redutases
NEUROSCIENCES
Prognosis
PSYCHIATRY
Recovery of Function - drug effects
Retrospective Studies
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Summary:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been associated with improved clinical outcomes after ischemic stroke and subarachnoid hemorrhage, but with an increased risk of incidental spontaneous intracerebral hemorrhage (ICH). We investigated whether the statin use before ICH, was associated with functional independence, 90 days after treatment. We analyzed 124 consecutive ICH patients with 90-day outcome data who were enrolled in a prospective cohort study between 2006 and 2009. Eighty-three patients were included in this study. Among ICH survivors, univariate Cox regression models and Kaplan-Meier plots were used to determine subject characteristics that were associated with an increased risk of recurrence. Statin usage was determined through interviewing the patient at the time of ICH and confirmed by reviewing their medical records. Independent status was defined as Glasgow Outcome Scale grades 4 or 5. Statins were used by 20 out of 83 patients (24%) before ICH onset. There was no effect from pre-ICH statin use on functional independence rates (28% versus 29%, P=0.84) or mortality (46% versus 45%, P=0.93). Pre-ICH statin use is not associated with changes to ICH functional outcome or mortality.
ISSN:0004-282X
1678-4227
1678-4227
0004-282X
DOI:10.1590/S0004-282X2011000400008