Impact of autoantibody status on stratifying the risk of organ involvement and mortality in SSc: experience from a multicentre French cohort of 1605 patients

• Published in: Rheumatic & musculoskeletal diseases open 2024-11, Vol.10 (4), p.e004580
• Main Authors: Didier, Kevin, Sobanski, Vincent, Robbins, Ailsa, Truchetet, Marie-Elise, Barnetche, Thomas, Contin-Bordes, Cécile, Hot, Arnaud, Fort, Romain, Guilpain, Philippe, Maria, Alexandre, Agard, Christian, Pennaforte, Jean-Loup, Viguier, Manuelle, Martin, Thierry, Jolly, Damien, Barbe, Coralie, Giusti, Delphine, Launay, David, Servettaz, Amélie
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antibodies; Antibodies, Antinuclear - blood; Antibodies, Antinuclear - immunology; Arthritis; autoantibodies; Autoantibodies - blood; Autoantibodies - immunology; Biopsy; Classification; Disease; Female; France - epidemiology; Genotype & phenotype; Humans; Hypertension; Life Sciences; Male; Medical prognosis; Middle Aged; Mortality; Original Research; Pathogenesis; Patients; Prognosis; Retrospective Studies; RNA polymerase; Scleroderma; Scleroderma, Systemic - diagnosis; Scleroderma, Systemic - immunology; Scleroderma, Systemic - mortality; Systemic Sclerosis
• ISSN: 2056-5933; 2056-5933
• DOI: 10.1136/rmdopen-2024-004580

IntroductionSystemic sclerosis (SSc) is a rare autoimmune disease currently classified into two subgroups based on skin extension. The aim of this study was to determine in a large cohort whether the determination of autoantibody (AAb) profile among a full antinuclear AAbs panel including nine specificities had a higher impact than skin phenotype on stratifying the risk of organ involvement and mortality in SSc.MethodsData for patients with SSc followed in seven French university hospitals were retrospectively analysed in terms of skin phenotype, AAbs (anti-topoisomerase I (ATA), anticentromere (ACA), anti-RNA polymerase III (anti-RNAPIII), anti-U1RNP, anti-U3RNP, anti-Pm/Scl, anti-Ku, anti-Th/To, anti-NOR90), organ involvement and mortality. Multivariate analyses were performed to identify independent factors associated with organ involvement and mortality.ResultsWe included 1605 patients with SSc (367 with diffuse cutaneous SSc). On multivariate analysis, ATAs were associated with interstitial lung disease and mortality (OR=3.27 (95% CI 2.42 to 4.42); HR=1.9 (95% CI 1.01 to 3.58)), anti-RNAPIII with scleroderma renal crisis and mortality (OR=7.05 (95% CI 2.98 to 16.72); HR=2.35 (95% CI 1.12 to 4.93)), anti-U1RNP with arthritis (OR=3.79 (95% CI 2.16 to 6.67)), anti-Pm/Scl and anti-Ku with myositis (OR=7.09 (95% CI 3.87 to 12.98) and 7.99 (95% CI 2.41 to 26.46)). The skin phenotype was not associated with survival or organ involvement on multivariate analysis without stepwise selection.ConclusionThis study unravels, by contrast with skin phenotype, a strong association between AAbs specificities, organ involvement and outcome in SSc and suggests that patients’ classification based on only skin extension is not sufficient for defining prognosis and phenotype.