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Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures
: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the...
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| Published in: | Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-11, Vol.17 (12), p.1594 |
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| container_issue | 12 |
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| container_title | Pharmaceuticals (Basel, Switzerland) |
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| creator | Delgado, Daniel Ricardo Castro-Camacho, Jennifer Katiusca Ortiz, Claudia Patricia Caviedes-Rubio, Diego Ivan Martinez, Fleming |
| description | : Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical-pharmaceutical interest.
: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry.
: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion.
: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation. |
| doi_str_mv | 10.3390/ph17121594 |
| format | article |
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: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry.
: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion.
: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation.</description><identifier>ISSN: 1424-8247</identifier><identifier>EISSN: 1424-8247</identifier><identifier>DOI: 10.3390/ph17121594</identifier><identifier>PMID: 39770436</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>1-propanol ; Acetonitrile ; Chemical industry ; cosolvency ; Infections ; Pharmaceutical industry ; solubility ; solution thermodynamics ; Solvents ; sulfamethazine ; Temperature ; Thermodynamics ; Veterinary medicine</subject><ispartof>Pharmaceuticals (Basel, Switzerland), 2024-11, Vol.17 (12), p.1594</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2526-d6714a8a1e3310dbe5f19e78d262eef006b98f04076641f042b323a58edb27fb3</cites><orcidid>0000-0002-7977-701X ; 0000-0002-6101-9114 ; 0000-0002-4835-9739 ; 0000-0002-4008-7273 ; 0000-0002-8766-9158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3149740750/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3149740750?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,36990,44566,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39770436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delgado, Daniel Ricardo</creatorcontrib><creatorcontrib>Castro-Camacho, Jennifer Katiusca</creatorcontrib><creatorcontrib>Ortiz, Claudia Patricia</creatorcontrib><creatorcontrib>Caviedes-Rubio, Diego Ivan</creatorcontrib><creatorcontrib>Martinez, Fleming</creatorcontrib><title>Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures</title><title>Pharmaceuticals (Basel, Switzerland)</title><addtitle>Pharmaceuticals (Basel)</addtitle><description>: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical-pharmaceutical interest.
: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry.
: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion.
: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation.</description><subject>1-propanol</subject><subject>Acetonitrile</subject><subject>Chemical industry</subject><subject>cosolvency</subject><subject>Infections</subject><subject>Pharmaceutical industry</subject><subject>solubility</subject><subject>solution thermodynamics</subject><subject>Solvents</subject><subject>sulfamethazine</subject><subject>Temperature</subject><subject>Thermodynamics</subject><subject>Veterinary medicine</subject><issn>1424-8247</issn><issn>1424-8247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkktv1DAQxyMEog-48AFQJC4tKMWv2PFx1QdUKgKp5Ww5zrjrVWJvbUdi-fT1sqUFhHzwaPyb_zw8VfUGoxNKJfq4XmKBCW4le1btY0ZY0xEmnv9h71UHKa0QagVm-GW1R6UQiFG-X9kzl1IY5-yCr2-WEKcwbLyenEl1sHVeQn1dnns3urzZeq7n0eoJ8lL_dB5q5-ujhYEcvMvRjVB_qHHzLYa19mE8rr-4H3mOkF5VL6weE7x-uA-r7xfnN6efm6uvny5PF1eNIS3hzcBLgbrTGCjFaOihtViC6AbCCYBFiPeys4ghwTnDxSA9JVS3HQw9Ebanh9XlTncIeqXW0U06blTQTv1yhHirdMzOjKCQpt3AythoDww6Lo2lpuWM9VQaTlnROtpprWO4myFlNblkYBy1hzAnRUtoJzBqaUHf_YOuwhx96bRQTIpScIueqFtd8jtvQ47abEXVoiNYYs6ELNTJf6hyBii_EjzYMua_A97vAkwMKUWwj31jpLYLop4WpMBvHyqd-wmGR_T3RtB72SyyOw</recordid><startdate>20241126</startdate><enddate>20241126</enddate><creator>Delgado, Daniel Ricardo</creator><creator>Castro-Camacho, Jennifer Katiusca</creator><creator>Ortiz, Claudia Patricia</creator><creator>Caviedes-Rubio, Diego Ivan</creator><creator>Martinez, Fleming</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7977-701X</orcidid><orcidid>https://orcid.org/0000-0002-6101-9114</orcidid><orcidid>https://orcid.org/0000-0002-4835-9739</orcidid><orcidid>https://orcid.org/0000-0002-4008-7273</orcidid><orcidid>https://orcid.org/0000-0002-8766-9158</orcidid></search><sort><creationdate>20241126</creationdate><title>Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures</title><author>Delgado, Daniel Ricardo ; Castro-Camacho, Jennifer Katiusca ; Ortiz, Claudia Patricia ; Caviedes-Rubio, Diego Ivan ; Martinez, Fleming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2526-d6714a8a1e3310dbe5f19e78d262eef006b98f04076641f042b323a58edb27fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>1-propanol</topic><topic>Acetonitrile</topic><topic>Chemical industry</topic><topic>cosolvency</topic><topic>Infections</topic><topic>Pharmaceutical industry</topic><topic>solubility</topic><topic>solution thermodynamics</topic><topic>Solvents</topic><topic>sulfamethazine</topic><topic>Temperature</topic><topic>Thermodynamics</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delgado, Daniel Ricardo</creatorcontrib><creatorcontrib>Castro-Camacho, Jennifer Katiusca</creatorcontrib><creatorcontrib>Ortiz, Claudia Patricia</creatorcontrib><creatorcontrib>Caviedes-Rubio, Diego Ivan</creatorcontrib><creatorcontrib>Martinez, Fleming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest_Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceuticals (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delgado, Daniel Ricardo</au><au>Castro-Camacho, Jennifer Katiusca</au><au>Ortiz, Claudia Patricia</au><au>Caviedes-Rubio, Diego Ivan</au><au>Martinez, Fleming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures</atitle><jtitle>Pharmaceuticals (Basel, Switzerland)</jtitle><addtitle>Pharmaceuticals (Basel)</addtitle><date>2024-11-26</date><risdate>2024</risdate><volume>17</volume><issue>12</issue><spage>1594</spage><pages>1594-</pages><issn>1424-8247</issn><eissn>1424-8247</eissn><abstract>: Solubility is one of the most important parameters in the research and development processes of the pharmaceutical industry. In this context, cosolubility is one of the most used strategies to improve the solubility of poorly soluble drugs, besides allowing to identify some factors involved in the dissolution process. The aim of this research is to evaluate the solubility of sulfamethazine in acetotinitrile + 1-propanol cosolvent mixtures at 9 temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, 313.15, and 318.15 K); a drug used in human and veterinary therapy and two solvents of great chemical-pharmaceutical interest.
: The determination was carried out by the shaking flask method and the drug was quantified by UV/Vis spectrophotometry.
: The solubility of sulfamethazine increases from pure 1-propanol (solvent in which it reaches its lowest solubility at 278.15 K) to pure acetonitrile (solvent in which it reaches its maximum solubility at 318.15 K), behaving in a logarithmic-linear fashion.
: The increase in solubility is related to the acid/base character of the cosolvent mixtures and not to the solubility parameter of the mixtures. The dissolution process is endothermic and favored by the solution entropy, and also shows a strong entropic compensation.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39770436</pmid><doi>10.3390/ph17121594</doi><orcidid>https://orcid.org/0000-0002-7977-701X</orcidid><orcidid>https://orcid.org/0000-0002-6101-9114</orcidid><orcidid>https://orcid.org/0000-0002-4835-9739</orcidid><orcidid>https://orcid.org/0000-0002-4008-7273</orcidid><orcidid>https://orcid.org/0000-0002-8766-9158</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 1-propanol Acetonitrile Chemical industry cosolvency Infections Pharmaceutical industry solubility solution thermodynamics Solvents sulfamethazine Temperature Thermodynamics Veterinary medicine |
| title | Dissolution Thermodynamics of the Solubility of Sulfamethazine in (Acetonitrile + 1-Propanol) Mixtures |
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