A Novel Zein-Based Composite Nanoparticles for Improving Bioaccessibility and Anti-Inflammatory Activity of Resveratrol

A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanopartic...

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Bibliographic Details
Published in:Foods 2021-11, Vol.10 (11), p.2773
Main Authors: Liu, Jiaping, Zhang, Yaqiong, Liu, Wenwen, Gao, Boyan, Yu, Liangli (Lucy)
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Anti-inflammatory agents
Aqueous solutions
Binding sites
bioaccessibility
Bioavailability
cross-linked sodium caseinate
Cytotoxicity
Encapsulation
Ethanol
Food
Food science
Hydrogen bonding
Hydrophobicity
Inflammation
Laboratories
Mass ratios
Microorganisms
Microscopy
Nanoparticles
Particle size
Resveratrol
Sodium
Spectrum analysis
Toxicity
Zein
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Summary:A microbial transglutaminase-induced cross-linked sodium caseinate (MSC) was used to stabilize zein nanoparticles, and the study was to investigate whether zein-MSC nanoparticles (zein-MSC NPs) can be used as an encapsulation carrier for resveratrol. A group of resveratrol-loaded zein-MSC nanoparticles (Res-zein-MSC NPs) with varying zein to Res mass ratios was first prepared. The particle sizes and zeta-potentials were in the ranges from 215.00 to 225.00 nm and from −29.00 to −31.00 mV. The encapsulation efficiency (EE) of Res was also influenced by the zein to Res mass ratio, and the encapsulated Res existed in an amorphous form. The major interactions between Res and zein-MSC NPs were hydrogen bonding and hydrophobic interaction. Furthermore, compared with free Res, the photo-stability and bioaccessibility of Res-zein-MSC NPs were significantly improved. The cellular studies also showed that Res-zein-MSC NPs exhibited lower cytotoxicity and desirable anti-inflammatory activity.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods10112773