Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study

During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalis...

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Published in:Memórias do Instituto Oswaldo Cruz 2009-09, Vol.104 (6), p.905-913
Main Authors: Martins, CAS, Faria, LMD, Souza, MC, Camello, TCF, Velasco, E, Hirata, R Jr, Thuler, LCS, Mattos-Guaraldi, AL
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
cancer
Catheter-Related Infections - microbiology
Catheters, Indwelling - microbiology
Corynebacterium - classification
Corynebacterium - isolation & purification
Corynebacterium amycolatum
Corynebacterium amycolatum - Corynebacterium infection - cancer
Corynebacterium infection
Corynebacterium Infections - microbiology
Cross Infection - microbiology
Female
Humans
Male
Neoplasms - microbiology
PARASITOLOGY
Retrospective Studies
Risk Factors
TROPICAL MEDICINE
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Summary:During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalised (71.1% from surgical wards). The adult solid tumour was the most common underlying malignant disease (66.7%). The univariate and multivariate analyses showed that hospitalised patients had a six-fold greater risk (OR = 5.5, 95% CI = 1.15-26.30 p = 0.033) related to 30-day mortality. The predominant species were Corynebacterium amycolatum (44.7%), Corynebacterium minutissimum (18.3%) and Corynebacterium pseudodiphtheriticum (8.5%). The upper urinary tracts, surgical wounds, lower respiratory tracts, ulcerated tumours and indwelling venous catheters were the most frequent sources of C. amycolatum strains. Corynebacterium jeikeium infection occurred primarily in neutropenic patients who have used venous catheters, while infection caused by C. amycolatum and other species emerged mainly in patients with solid tumours.
ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762009000600015