Post VV-ECMO Weaning Hyperinflammation—Can Prophylactic Hemoadsorption Treatment Prevent Complications?

Acute respiratory distress syndrome (ARDS) is a severe clinical condition characterized by acute respiratory failure and a high mortality risk despite conventional mechanical ventilatory support. Veno-venous extracorporeal membrane oxygenation (vvECMO) has emerged as an effective life-support techno...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2023-10, Vol.59 (10), p.1818
Main Authors: Kovacevic, Pedja, Dragic, Sasa, Jandric, Milka, Momcicevic, Danica, Topolovac, Sandra, Malesevic, Vedrana, Kovacevic, Tijana, Matejic-Spasic, Marijana, Knezevic, Tanja, Zlojutro, Biljana
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Antibiotics
Case Report
Cytokines
CytoSorb
Development and progression
ECMO
Extracorporeal membrane oxygenation
Fever
Gynecology
Health aspects
hemoadsorption
hyperinflammation
Intubation
Laboratories
Mortality
Ostomy
Patients
Pneumonia
Prevention
Respiratory failure
Respiratory system
Sepsis
United Kingdom
Ventilators
Weaning
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Summary:Acute respiratory distress syndrome (ARDS) is a severe clinical condition characterized by acute respiratory failure and a high mortality risk despite conventional mechanical ventilatory support. Veno-venous extracorporeal membrane oxygenation (vvECMO) has emerged as an effective life-support technology for patients with ARDS. However, complications may arise following the decannulation of vvECMO, with a relatively frequent development of systemic hyperinflammation (SHI). Among the various treatment strategies for SHI, the use of hemoadsorption with CytoSorb® has shown promising results in removing excessive levels of cytokines and attenuating the hyperinflammatory response. In this case series, we present three critically ill patients with ARDS secondary to pneumonia who underwent vvECMO and subsequently received prophylactic hemoadsorption with CytoSorb® following decannulation as a part of our clinical practice. This case series aims to describe the potential positive effects of hemoadsorption in preventing the development of SHI after vvECMO decannulation in ARDS patients.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59101818