Exploring the Feasibility and Effects of a Ketogenic Diet in Patients With CNS Malignancies: A Retrospective Case Series

Background: Recently, the ketogenic diet has been proposed as an adjunct treatment for a range of medical conditions including weight loss, cancer, and neurodegenerative diseases. Because malignant CNS tumors are highly dependent on glucose, the use of a ketogenic diet as an adjunct therapy is curre...

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Bibliographic Details
Published in:Frontiers in neuroscience 2020-05, Vol.14, p.390-390
Main Authors: Panhans, Cristina M., Gresham, Gillian, Amaral, L. J., Hu, Jethro
Format: Article
Language:English
Subjects:
Astrocytoma
Atkins
Body weight loss
Brain cancer
Cancer therapies
Carbohydrates
Chemotherapy
Clinical trials
Diet
Dietitians
Disease control
Edema
Gene expression
Glioblastoma
glioma
Glucose
High fat diet
Ketogenesis
ketogenic diet
Ketones
Low carbohydrate diet
Meals
Neurodegenerative diseases
Neuroimaging
Neuroscience
Nutrient deficiency
Oligodendroglioma
Patients
Proteins
Quantitative analysis
Radiation therapy
Spinal cord
Tumors
Warburg effect
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Summary:Background: Recently, the ketogenic diet has been proposed as an adjunct treatment for a range of medical conditions including weight loss, cancer, and neurodegenerative diseases. Because malignant CNS tumors are highly dependent on glucose, the use of a ketogenic diet as an adjunct therapy is currently being explored. Controlled clinical evidence is lacking, but further studies are merited to determine the effect of a ketogenic diet and CNS malignancies. The purpose of this case series serves to explore the potential for a ketogenic for patients with CNS malignancies. Methods: Patients diagnosed with CNS malignancies following a ketogenic diet were identified between 2015 and 2017. Malignancies included a confirmed diagnosis of glioblastoma, astrocytoma, or oligodendroglioma. With guidance from a registered dietitian, ketone, glucose, and weight were regularly collected for several patients along with patient reported symptoms and side effects. Interested patients were recommended to follow a 3:1 ketogenic diet for 120 days. The ketogenic diet is a high-fat, moderate protein, and very low carbohydrate diet, where patients limited carbohydrate intake to
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2020.00390