GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate...

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Bibliographic Details
Published in:Diabetology and metabolic syndrome 2021-02, Vol.13 (1), p.20-20, Article 20
Main Authors: Zahedi, Asiyeh Sadat, Akbarzadeh, Mahdi, Sedaghati-Khayat, Bahareh, Seyedhamzehzadeh, Atefeh, Daneshpour, Maryam S
Format: Article
Language:English
Subjects:
Alleles
Analysis
Biomarkers
Blood pressure
Blood sugar
Cohort analysis
Diabetes
Disease
Fasting
GCKR
Genetic aspects
Glucokinase
Glucose
High density lipoprotein
Hypertension
Insulin resistance
Isoenzymes
Laboratory testing
Lipids
Medical research
Medicine, Experimental
Metabolic syndrome
Obesity
Population
Risk factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Triglyceride
Triglycerides
Type 2 diabetes
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Summary:Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association with the favorable and unfavorable metabolic syndrome components. We decided to evaluate these findings in a cohort study with a large sample size of Iranian adult subjects, to our knowledge for the first time. We investigated the association of the GCKR variants with incident MetS in mean follow-up times for nearly 10 years. Analysis of this retrospective cohort study was performed among 5666 participants of the Tehran Cardiometabolic Genetics Study (TCGS) at 19-88 years at baseline. Linear and logistic regression analyses were used to investigate the metabolic syndrome (JIS criteria) association and its components with rs780093, rs780094, and rs1260326 in an additive genetic model. Cox regression was carried out to peruse variants' association with the incidence of metabolic syndrome in the TCGS cohort study. In the current study, we have consistently replicated the association of the GCKR SNPs with higher triglyceride and lower fasting blood sugar levels (p 
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-021-00637-4