Muscular dystrophy patients show low exercise‐induced blood flow in muscles with normal strength

Objective Neuromuscular evaluation increasingly employs muscle ultrasonography to determine muscle thickness, mean grayscale echointensity, and visual semiquantitative echotexture attenuation. However, these measures provide low sensitivity for detection of mild muscle abnormality. Exercise‐induced...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2024-11, Vol.11 (11), p.2866-2876
Main Authors: Gera, Orna, Shavit‐Stein, Efrat, Amichai, Taly, Chapman, Joab, Chorin, Odelia, Greenbaum, Lior, Dori, Amir
Format: Article
Language:English
Subjects:
Adult
Aged
Charcot-Marie-Tooth Disease - diagnostic imaging
Charcot-Marie-Tooth Disease - physiopathology
Exercise - physiology
Female
Humans
Ischemia
Male
Males
Middle Aged
Muscle strength
Muscle Strength - physiology
Muscle, Skeletal - blood supply
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - physiopathology
Muscular Dystrophies - diagnostic imaging
Muscular Dystrophies - physiopathology
Muscular dystrophy
Muscular Dystrophy, Duchenne - diagnostic imaging
Muscular Dystrophy, Duchenne - physiopathology
Musculoskeletal system
Patients
Regional Blood Flow - physiology
Software
Ultrasonic imaging
Ultrasonography
Variables
Young Adult
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Summary:Objective Neuromuscular evaluation increasingly employs muscle ultrasonography to determine muscle thickness, mean grayscale echointensity, and visual semiquantitative echotexture attenuation. However, these measures provide low sensitivity for detection of mild muscle abnormality. Exercise‐induced intramuscular blood flow is a physiologic phenomenon, which may be impaired in mildly affected muscles, particularly in dystrophinopathies, and may indicate functional muscle ischemia. We aimed to determine if muscle blood flow is reduced in patients with neuromuscular disorders and preserved muscle strength, and if it correlates with echointensity and digital echotexture measurements. Methods Peak exercise‐induced blood flow, echointensity, and echotexture were quantified in the elbow flexor muscles of 15 adult patients with Becker muscular dystrophy (BMD) and 13 patients with other muscular dystrophies (OMD). These were compared to 17 patients with Charcot–Marie–Tooth type 1 (CMT1) neuropathy and 21 healthy adults from a previous study. Results Muscle blood flow was reduced in all patient groups compared to controls, most prominently in BMD patients (p 
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.52194