Dependence receptors: new targets for cancer therapy

Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing ca...

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Bibliographic Details
Published in:EMBO molecular medicine 2021-11, Vol.13 (11), p.1-n/a
Main Authors: Brisset, Morgan, Grandin, Mélodie, Bernet, Agnès, Mehlen, Patrick, Hollande, Frédéric
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Cancer
cancer hallmarks
Cancer therapies
Chemoresistance
EMBO03
EMBO07
EMBO37
Invasiveness
Kinases
Life Sciences
Ligands
Morphogenesis
Proteins
Review
Signal transduction
treatment resistance
tumor progression
Tumorigenesis
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Summary:Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro‐apoptotic functions of these proteins. Graphical Abstract Upon activation, dependence receptors promote survival, proliferation and migration but when unbound to their ligand, they trigger apoptosis. Here, F. Hollande & colleagues review the current knowledge on their contribution to cancer and discuss the therapeutic potential of targeting these receptors.
ISSN:1757-4676
1757-4684
DOI:10.15252/emmm.202114495