Dynamic Changes of Arc Expression in Dorsal Striatum of Mice After Self-Administration of Sucrose

Region-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes during motor skill processes have documented...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2021-05, Vol.15, p.654521-654521
Main Authors: Li, Xue, Zhao, Jing-Wang, Ding, Qian, Wu, Cheng, Li, Wan-Qi, Guo, Yan-Chen, Wang, Di, Xu, Guang-Qing, Yuan, Ti-Fei, Gong, Wan-Kun, Lan, Yue
Format: Article
Language:English
Subjects:
Animals
Arc
ARC protein
Behavior
Brain
Caudate-putamen
Cytoskeleton
Experiments
instrumental learning
Learning
Motor skill
Motor skill learning
Neostriatum
Neuroscience
Plasticity
Reinforcement
Self-administration
Software
Statistical analysis
Sucrose
the dorsolateral striatum
the dorsomedial striatum
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Summary:Region-specific plasticity in the striatal circuit plays an important role in the development and long-term maintenance of skills and sequential movement procedures. Studies investigating the molecular substrates that contribute to the plasticity changes during motor skill processes have documented a transition in expression from the dorsomedial striatum (DMS) to the dorsolateral striatum (DLS); however, few studies have explored the expression pattern of molecular substrates in the dorsal striatum during progression of instrumental learning. To address this issue, the activity-regulated cytoskeleton-associated protein (Arc) expressions in the subregional dorsal striatum were analyzed during the early and late learning phases of the 10-day sucrose self-administration process. We found that Arc protein is primarily detected in the DMS only in the initial learning stage; however, it is expressed in the DLS during both early and late learning stages. Moreover, Arc expression in the DMS correlated with the number of rewards received later in the training. These data indicated that the Arc expression in subregions of the dorsal striatum shows region-specific transfer and that Arc expression in the DMS contributes to obtaining reward in later learning stage during the process of instrumental learning.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2021.654521