Nitric oxide‐mediated cutaneous microvascular function is not altered in middle‐aged‐to‐older adults following mild SARS‐CoV‐2 infection: A pilot study

We tested the hypothesis that post‐COVID‐19 adults (PC) would have impaired cutaneous nitric oxide (NO)‐mediated vasodilation compared to controls (CON). We performed a cross‐sectional study including 10 (10 F/0 M, 69 ± 7 years) CON and 7 (2 F/5 M, 66 ± 8 years) PC (223 ± 154 days post‐diagnosis). C...

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Bibliographic Details
Published in:Physiological reports 2023-06, Vol.11 (11), p.e15704-n/a
Main Authors: Dillon, Gabrielle A., Wolf, S. Tony, Williams, Auni C., Kenney, W. Larry, Alexander, Lacy M.
Format: Article
Language:English
Subjects:
Aged
aging
Arginine
Blood pressure
Body mass index
Cardiovascular disease
COVID-19
Cross-Sectional Studies
Diagnosis
Doppler effect
Erythrocytes
Hormone replacement therapy
Humans
Hypertension
Infections
Medical screening
Microdialysis
Microvasculature
Middle age
Middle Aged
NG-Nitroarginine Methyl Ester
Nitric Oxide
Older people
Original
Physiology
Pilot Projects
Regional Blood Flow
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Skin - blood supply
Sodium nitroprusside
Vasodilation
Vasodilation - physiology
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Summary:We tested the hypothesis that post‐COVID‐19 adults (PC) would have impaired cutaneous nitric oxide (NO)‐mediated vasodilation compared to controls (CON). We performed a cross‐sectional study including 10 (10 F/0 M, 69 ± 7 years) CON and 7 (2 F/5 M, 66 ± 8 years) PC (223 ± 154 days post‐diagnosis). COVID‐19 symptoms severity (survey) was assessed (0–100 scale for 18 common symptoms). NO‐dependent cutaneous vasodilation was induced by a standardized 42°C local heating protocol and quantified via perfusion of 15 mM NG‐nitro‐L‐arginine methyl ester during the plateau of the heating response (intradermal microdialysis). Red blood cell flux was measured with laser‐Doppler flowmetry. Cutaneous vascular conductance (CVC = flux/mm Hg) was presented as a percentage of maximum (28 mM sodium nitroprusside +43°C). All data are means ± SD. The local heating plateau (CON: 71 ± 23% CVCmax vs. PC: 81 ± 16% CVCmax, p = 0.77) and NO‐dependent vasodilation (CON: 56 ± 23% vs. PC: 60 ± 22%, p = 0.77) were not different between groups. In the PC group neither time since diagnosis nor peak symptom severity (46 ± 18 AU) correlated with NO‐dependent vasodilation (r 
ISSN:2051-817X
DOI:10.14814/phy2.15704