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Polyamine Homeostasis in Development and Disease

Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet their underlying mechanisms of action are not fully un...

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Published in:	Medical sciences (Basel) 2021-05, Vol.9 (2), p.28
Main Authors:	Nakanishi, Shima, Cleveland, John L
Format:	Article
Language:	English
Subjects:	Age Aging Autophagy Biosynthesis Cancer Cardiomyocytes Cell Proliferation development Enzymes Homeostasis Humans Insects Mammals Metabolism Nematodes Neoplasms - drug therapy Neuroblastoma Polyamines Polyamines - metabolism Review Yeast
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description	Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet their underlying mechanisms of action are not fully understood. Several studies have shown both beneficial and detrimental effects of polyamines on human health. In cancer, polyamine metabolism is frequently dysregulated, and elevated polyamines have been shown to promote tumor growth and progression, suggesting that targeting polyamines is an attractive strategy for therapeutic intervention. In contrast, polyamines have also been shown to play critical roles in lifespan, cardiac health and in the development and function of the brain. Accordingly, a detailed understanding of mechanisms that control polyamine homeostasis in human health and disease is needed to develop safe and effective strategies for polyamine-targeted therapy.
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subjects	Age Aging Autophagy Biosynthesis Cancer Cardiomyocytes Cell Proliferation development Enzymes Homeostasis Humans Insects Mammals Metabolism Nematodes Neoplasms - drug therapy Neuroblastoma Polyamines Polyamines - metabolism Review Yeast
title	Polyamine Homeostasis in Development and Disease
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