Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer

• Published in: BMC cancer 2018-05, Vol.18 (1), p.545-545, Article 545
• Main Authors: Park, Jae Won, Koh, Dong Hoon, Jang, Won Sik, Cho, Kang Su, Ham, Won Sik, Rha, Koon Ho, Hong, Sung Joon, Choi, Young Deuk
• Format: Article
• Language: English
• Subjects: Adverse pathologic features; Aged; Biopsy; Diagnosis; Humans; Low-risk prostate cancer; Male; Margins of Excision; Middle Aged; Needle biopsy; Neoplasm Grading; Neoplasm Invasiveness - pathology; Neoplasm Recurrence, Local - prevention & control; Prostate - pathology; Prostate - surgery; Prostate cancer; Prostate-Specific Antigen - blood; Prostatectomy; Prostatectomy - adverse effects; Prostatic Neoplasms - blood; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Radical prostatectomy; Retrospective Studies; Risk factors; Seminal Vesicles - pathology; Treatment Outcome; Watchful Waiting
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-018-4416-4

Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous related studies had utilized outdated staging criteria or small sample cohorts. In this study, we analyzed predictors of APFs after RP in low-risk PC using classification under the current criteria. We retrospectively reviewed medical records of 546 low-risk PC patients who had undergone RP. Low-risk PC was defined as PC with clinical T1-T2a, Gleason score ≤ 6, and PSA levels  4.5 ng/mL and number of positive cores > 2 in low-risk PC were significantly associated with APFs, and suggested as cut-off values for predicting APFs. PSA > 4.5 ng/mL and number of positive cores > 2 in low-risk PC were associated with presence of APFs and patients with such records should be considered carefully to provide active surveillance.