The efficacy of the combination of venetoclax and hypomethylating agents versus HAG agents in patients with acute myeloid leukemia: a retrospective study

• Published in: Hematology (Luxembourg) 2024-12, Vol.29 (1), p.2350319-2350319
• Main Authors: Xin, Fei, Yu, Yan-Hui, Shen, Xu-Liang, Zhang, Guo-Xiang
• Format: Article
• Language: English
• Subjects: Acute myeloid leukemia; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Azacitidine - administration & dosage; Azacitidine - therapeutic use; Bridged Bicyclo Compounds, Heterocyclic - therapeutic use; complete remission; Female; HAG regimen; Humans; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - mortality; Male; Middle Aged; newly diagnosed; overall survival; Retrospective Studies; Sulfonamides - administration & dosage; Sulfonamides - therapeutic use; Treatment Outcome; venetoclax
• ISSN: 1607-8454; 1607-8454
• DOI: 10.1080/16078454.2024.2350319

The purpose of this study was to compare the effectiveness of the combination of venetoclax and hypomethylating agents with the HAG regimen. We studied 52 cases of newly diagnosed AML and 26 cases of relapsed refractory AML, (including AML patients with treatment-related and ELN-adverse risk disease (n = 50)). These patients were treated with venetoclax and hypomethylating agents and HAG regimens, respectively. Twenty-nine patients newly diagnosed with acute myeloid leukemia were treated with VEN-HMA (venetoclax-hypomethylating agent), while 23 patients were treated with HAG. The median age of the VEN-HMA group was 70 years, while the HAG group had a median age of 69 years. The VEN-HMA group achieved a significantly higher rate of complete remission (82.7%) compared to the cohort treated with the HAG regimen (21.7%) (  0.99). The median overall survival was similar between the VEN-HMA and HAG groups, with 4 and 3.67 months, respectively ( = 0.290). In conclusion, our analyses indicated that VEN-HMA resulted in better therapeutic outcomes compared to HAG for newly diagnosed AML patients, with higher rates of complete remission and overall survival. In relapsed/refractory AML patients, there was no significant difference in the efficacy of the two treatments and further studies with larger sample sizes are warranted.