Evaluation of selected semen parameters and biomarkers of male infertility - preliminary study [version 1; peer review: 1 approved]

Background: Because the etiopathogenesis of male infertility is multifactorial our study was designed to clarify the relationship between standard semen parameters, testicular volume, levels of reproductive hormones and the fragmentation of sperm nuclear DNA (SDF). Methods: Patients (n = 130) were c...

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Bibliographic Details
Published in:F1000 research 2022, Vol.11, p.591
Main Authors: Kups, Michal, Gill, Kamil, Rosiak-Gill, Aleksandra, Harasny, Patryk, Machalowski, Tomasz, Grabowska, Marta, Kurzawa, Rafal, Sipak, Olimpia, Piasecka, Malgorzata
Format: Article
Language:English
Subjects:
Antibodies
Biomarkers
Chromatin
DNA damage
DNA fragmentation
eng
Fertility
Follicle-stimulating hormone
Hormones
Infertility
Luteinizing hormone
male infertility
Morphology
Motility
Pregnancy
reproductive hormones
Reproductive technologies
Semen
semen characteristics
Sperm
sperm nuclear DNA integrity
Spermatogenesis
Testes
testicular volume
Thyroid gland
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Summary:Background: Because the etiopathogenesis of male infertility is multifactorial our study was designed to clarify the relationship between standard semen parameters, testicular volume, levels of reproductive hormones and the fragmentation of sperm nuclear DNA (SDF). Methods: Patients (n = 130) were clustered as subjects: 1) with an abnormal volume (utrasonography) of at least one testis (30%), moderate (>15-30%) or low (≤15%) (sperm chromatin dispersion test). Results: In subjects with a decreased testicular volume and in subjects with abnormal levels of reproductive hormones, decreased basic semen parameters were found. Participants with abnormal testicular volume had a higher percentage of SDF and a higher level of FSH (Mann-Whitney U test). In turn, men with a high level of SDF had lower testicular volume and conventional sperm parameters than men with a low level of SDF (Kruskal-Wallis test). Conclusions: We showed that spermatogenesis disorders coexisted with decreased testicular volume and increased FSH levels. The disorders of spermatogenesis were manifested by reduced basic sperm characteristics and a high level of sperm nuclear DNA damage.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.121622.1