Lactobacillus protects the integrity of intestinal epithelial barrier damaged by pathogenic bacteria

Pathogens invade intestinal mucosal barrier through phagocytosis of antigen presenting cells (dendritic cell, microfold cells), or through the invasion into the intestinal epithelial directly. Some pathogens could damage the cell junction between epithelial cells and use the paracellular pathway as...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2015-03, Vol.5, p.26-26
Main Authors: Yu, Qinghua, Yuan, Lixia, Deng, Jun, Yang, Qian
Format: Article
Language:English
Subjects:
Caco-2 Cells
Enterotoxigenic Escherichia coli - physiology
Epithelial Cells - drug effects
Epithelial Cells - microbiology
Escherichia coli Infections - drug therapy
Escherichia coli Infections - microbiology
Escherichia coli Infections - prevention & control
Humans
IL-8
Intestines - cytology
Intestines - drug effects
Intestines - microbiology
Lactobacillus
Lactobacillus - physiology
Microbiology
mucosal barrier
paracellular permeability
Probiotics - pharmacology
Salmonella Infections - drug therapy
Salmonella Infections - microbiology
Salmonella Infections - prevention & control
Salmonella typhimurium - physiology
Tight Junctions
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Summary:Pathogens invade intestinal mucosal barrier through phagocytosis of antigen presenting cells (dendritic cell, microfold cells), or through the invasion into the intestinal epithelial directly. Some pathogens could damage the cell junction between epithelial cells and use the paracellular pathway as an entrance to invade. Moreover, some Lactobacillus could inhibit the adhesion of the pathogens and protect the integrity of the cell junction and mucosal barrier. This research focused on the potential therapeutic effect of Lactobacillus fructosus (L. fructosus) C2 to attenuate ETEC K88 or S. typhimurium SL1344 induced changes to mucosal barrier. The results demonstrated that treatment of polarized Caco-2 cells with L. fructosus C2 reduced the permeation of dextran, and expression of IL-8, p-ERK, and p-JNK when cells were infected with pathogenic bacteria. The findings indicated that L. fructosus C2 exerted a protective effect against the damage to the integrity of Caco-2 cells by ETEC or S. typhimurium infection.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2015.00026