The Role of Magnesium in the Pathogenesis of Metabolic Disorders

Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It is involved in many fundamental processes, and Mg deficiency is often correlated with negative health outcomes. On the one hand, most western civilizations consume less than the recommended daily allowance of M...

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Bibliographic Details
Published in:Nutrients 2022-04, Vol.14 (9), p.1714
Main Authors: Pelczyńska, Marta, Moszak, Małgorzata, Bogdański, Paweł
Format: Article
Language:English
Subjects:
Adipose tissue
Bioaccumulation
Blood
Body weight
Bones
Cardiac arrhythmia
Chronic illnesses
Complications
deficiency
diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - prevention & control
Electrolytes
Endothelium
Food
Glucose metabolism
Human body
Humans
Hypertension
Hypomagnesemia
Inflammation
Insulin
Insulin resistance
Insulin Resistance - physiology
Laboratories
Lipid metabolism
Lipids
Magnesium
Magnesium Deficiency - complications
Metabolic disorders
Methods
Normalizing
Nutrition research
Obesity
Obesity - metabolism
Pathogenesis
Review
Urine
Vasodilation
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Summary:Magnesium (Mg) is an essential nutrient for maintaining vital physiological functions. It is involved in many fundamental processes, and Mg deficiency is often correlated with negative health outcomes. On the one hand, most western civilizations consume less than the recommended daily allowance of Mg. On the other hand, a growing body of evidence has indicated that chronic hypomagnesemia may be implicated in the pathogenesis of various metabolic disorders such as overweight and obesity, insulin resistance (IR) and type 2 diabetes mellitus (T2DM), hypertension (HTN), changes in lipid metabolism, and low-grade inflammation. High Mg intake with diet and/or supplementation seems to prevent chronic metabolic complications. The protective action of Mg may include limiting the adipose tissue accumulation, improving glucose and insulin metabolism, enhancing endothelium-dependent vasodilation, normalizing lipid profile, and attenuating inflammatory processes. Thus, it currently seems that Mg plays an important role in developing metabolic disorders associated with obesity, although more randomized controlled trials (RCTs) evaluating Mg supplementation strategies are needed. This work represents a review and synthesis of recent data on the role of Mg in the pathogenesis of metabolic disorders.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14091714