Triglyceride–glucose index (TyG index) is a predictor of incident colorectal cancer: a population-based longitudinal study

• Published in: BMC endocrine disorders 2020-07, Vol.20 (1), p.1-113, Article 113
• Main Authors: Okamura, Takuro, Hashimoto, Yoshitaka, Hamaguchi, Masahide, Obora, Akihiro, Kojima, Takao, Fukui, Michiaki
• Format: Article
• Language: English
• Subjects: Alcohol; Blood pressure; Blood tests; Body mass index; Cancer; Cardiovascular disease; Cell adhesion & migration; Cholesterol; Cohort analysis; Cohort study; Colorectal cancer; Colorectal carcinoma; Creatinine; Dextrose; Diabetes; Diagnosis; Epidemiology; Fasting; Gene expression; Glucose; Hospitals; Insulin; Insulin resistance; Insulin-like growth factors; Laboratory testing; Longitudinal studies; Metabolism; Oncology, Experimental; Pathogenesis; Plasma; Population studies; Population-based studies; Questionnaires; Risk factors; Studies; Triglycerides; TyG index; Type 2 diabetes; Variance analysis
• ISSN: 1472-6823; 1472-6823
• DOI: 10.1186/s12902-020-00581-w

Background Colorectal cancer (CRC), which is related with insulin resistance, is a one of the most common cancers. Triglyceride-glucose index (TyG index) was made for a marker of insulin resistance. We conducted the investigation of association between TyG index and incident CRC. Methods We examined the affect of TyG index on incident CRC in this historical cohort study of 27,944 (16,454 men and 11,490 women) participants. TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. The impact of TyG index on incident CRC was investigated using Cox proportional hazard models, adjusting for sex, age, body mass index, smoking status, alcohol consumption, exercise, systolic blood pressure and creatinine. The covariate-adjusted receiver operating characteristic (ROC) curve calculated the area under the curve (AUC) and cut-off value of TyG index for the incidence of CRC. Results During the median 4.4-year follow-up, 116 participants were diagnosed as CRC. The cumulative incidence rate of CRC were 0.4%. In Cox proportional hazard model, the HRs of TyG index were 1.38 (95% Confidence interval (CI), 1.00–1.91, p = 0.049) after adjusting for covariates. In the covariate-adjusted ROC curve analysis, the cut-off value of TyG index for incident CRC was 8.272 (AUC 0.687 (95%CI, 0.637–737, sensitivity = 0.620, specificity = 0.668, p