YCl3-Catalyzed Highly Selective Ring Opening of Epoxides by Amines at Room Temperature and under Solvent-Free Conditions

A simple, efficient, and environmentally benign approach for the synthesis of β-amino alcohols is herein described. YCl3 efficiently carried out the ring opening of epoxides by amines to produce β-amino alcohols under solvent-free conditions at room temperature. This catalytic approach is very effec...

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Bibliographic Details
Published in:Catalysts 2017-11, Vol.7 (11), p.340
Main Authors: Natongchai, Wuttichai, Khan, Rais, Alsalme, Ali, Shaikh, Rafik
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
Aliphatic compounds
Amines
Catalysis
Catalysts
Chemical reactions
epoxides
Ethylene oxide
green chemistry
rare-earth metal catalysis
Regioselectivity
Ring opening
Room temperature
Solvents
β-amino alcohols
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Summary:A simple, efficient, and environmentally benign approach for the synthesis of β-amino alcohols is herein described. YCl3 efficiently carried out the ring opening of epoxides by amines to produce β-amino alcohols under solvent-free conditions at room temperature. This catalytic approach is very effective, with several aromatic and aliphatic oxiranes and amines. A mere 1 mol % concentration of YCl3 is enough to deliver β-amino alcohols in good to excellent yields with high regioselectivity.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal7110340