Episode of coexisting infections with multiple dengue virus serotypes in central Karnataka, India

Summary Background The co-circulation of multiple dengue virus serotypes has been reported in many parts of the world, including India; however, concurrent infection with more than one serotype of dengue virus in the same individual is rarely documented. Method An outbreak of dengue hemorrhagic feve...

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Bibliographic Details
Published in:Journal of infection and public health 2013-08, Vol.6 (4), p.302-306
Main Authors: VinodKumar, C.S, Kalapannavar, N.K, Basavarajappa, K.G, Sanjay, D, Gowli, Chandrasekar, Nadig, Naveen G, Prasad, B.S
Format: Article
Language:English
Subjects:
Adolescent
Arboviroses
Biological and medical sciences
Child
Child, Preschool
Coinfection - epidemiology
Coinfection - virology
Concurrent infection
Dengue fever
Dengue fevers
Dengue Virus - classification
Dengue Virus - isolation & purification
Female
Human viral diseases
Humans
India - epidemiology
Infectious Disease
Infectious diseases
Internal Medicine
Male
Medical sciences
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
RNA, Viral - genetics
RT-PCR
Serotyping
Severe Dengue - epidemiology
Severe Dengue - virology
Tropical viral diseases
Viral diseases
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Summary:Summary Background The co-circulation of multiple dengue virus serotypes has been reported in many parts of the world, including India; however, concurrent infection with more than one serotype of dengue virus in the same individual is rarely documented. Method An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Davangere, Karnataka, from June 2011–March 2012. This is the first report from India with a high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak. Acute phase sera from patients were tested for the presence of dengue virus RNA by RT-PCR. Results Of the 72 samples tested for dengue virus RNA, 42 (58.3%) were positive. All four dengue virus serotypes were found to be co-circulating in this outbreak, and DENV-2 was the predominant serotype. In addition, concurrent infection with more than one dengue virus serotype was identified in 18 (42.9%) dengue virus-positive samples. Conclusion Our study showed that serotype DEN-2 was dominant in the positive dengue virus-infected samples; the other serotype present was DEN-3. This is the first report of concurrent infections with different dengue virus serotypes in this part of the world.
ISSN:1876-0341
1876-035X
DOI:10.1016/j.jiph.2013.01.004