Next-Generation Ultrasol Curcumin Boosts Muscle Endurance and Reduces Muscle Damage in Treadmill-Exhausted Rats

Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively...

Full description

Saved in:
Bibliographic Details
Published in:Antioxidants 2021-10, Vol.10 (11), p.1692
Main Authors: Sahin, Emre, Orhan, Cemal, Erten, Fusun, Er, Besir, Acharya, Manutosh, Morde, Abhijeet A., Padigaru, Muralidhara, Sahin, Kazim
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
Bioavailability
Creatine
Creatine kinase
Curcumin
Cytokines
Exercise
exhaustion
Fatigue
Fitness equipment
Inflammation
L-Lactate dehydrogenase
Laboratory animals
Lactic acid
Malondialdehyde
Metabolism
Myoglobins
Physical fitness
Physiology
Polyphenols
Proteins
Rodents
Running
Software
Supplements
TOR protein
Tumor necrosis factor-TNF
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Curcumin positively affects performance during exercise and subsequent recovery. However, curcumin has limited bioavailability unless consumed in larger doses. In the current study, we examined the impact of a new formulation of curcumin, Next-Generation Ultrasol Curcumin (NGUC), which is relatively more bioavailable than natural curcumin on exhaustion time, grip strength, muscle damage parameters, and serum and muscle proteins. A total of 28 rats were randomly grouped as control (C, non-supplemented), exercise (E, non-supplemented), E+NGUC100 (supplemented with 100 mg/kg BW NGUC), and E+NGUC200 (supplemented with 200 mg/kg NGUC). Grip strength and exhaustion time were increased with NGUC supplementation (p < 0.0001). Creatine kinase (CK), lactate dehydrogenase (LDH), lactic acid (LA), myoglobin, malondialdehyde (MDA) concentrations were reduced in serum, and muscle tissue in NGUC supplemented groups (p < 0.05). In contrast, NGUC supplementation elevated the antioxidant enzyme levels compared to the non-supplemented exercise group (p < 0.01). Additionally, inflammatory cytokines were inhibited with NGUC administration (p < 0.05). NGUC decreased PGC-1α, p-4E-BP1, p-mTOR, MAFbx, and MuRF1 proteins in muscle tissue (p < 0.05). These results indicate that NGUC boosts exercise performance while reducing muscle damage by targeting antioxidant, anti-inflammatory, and muscle mass regulatory pathways.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10111692