Antihyperlipidemic Effects of Sesamum indicum L. in Rabbits Fed a High-Fat Diet

The present study aimed to investigate the anti-hyperlipidemic effects of sesame in a high-fat fed rabbit model. Animals were randomly divided into four groups of eight animals each for 60 days as follows: normal diet, hypercholesterolemic diet (1% cholesterol), hypercholesterolemic diet (1% cholest...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-5
Main Authors: Sahebkar, Amirhossein, Heidarian, Esfandiar, Najafi, Somayeh, Rafieian-Kopaei, Mahmoud, Asgary, Sedigheh
Format: Article
Language:English
Subjects:
Animals
Apolipoproteins
Apolipoproteins B - blood
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diet
Diet, High-Fat
Dietary Supplements
Feed additives
Food and nutrition
Glucose
Health aspects
High density lipoprotein
High fat diet
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Hypolipidemic Agents - therapeutic use
Insulin
Insulin - blood
Ketogenic diet
Lipid Metabolism - drug effects
Lipids
Low density lipoprotein
Oils & fats
Oilseeds
Phytochemicals
Rabbits
Random Allocation
Rodents
Seeds
Serum levels
Sesame
Sesame oil
Sesamum
Sesamum - chemistry
Sesamum indicum
Transaminases
Triglycerides
Triglycerides - blood
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Summary:The present study aimed to investigate the anti-hyperlipidemic effects of sesame in a high-fat fed rabbit model. Animals were randomly divided into four groups of eight animals each for 60 days as follows: normal diet, hypercholesterolemic diet (1% cholesterol), hypercholesterolemic diet (1% cholesterol) + sesame seed (10%), and hypercholesterolemic diet (1% cholesterol) + sesame oil (5%). Serum concentrations of total cholesterol, LDL-C, HDL-C, triglycerides, apoA and apoB, SGOT, SGPT, glucose and insulin were measured at the end of supplementation period in all studied groups. Hypercholesterolemic feeding resulted in a significant elevation of TC, TG, LDL-C, HDL-C, SGOT and SGPT as compared to the normocholesterolemic diet group (P0.05). In contrast, rabbits supplemented with sesame oil were found to have lower circulating concentrations of TC, LDL-C, HDL-C, SGOT and SGPT (P0.05). Supplementation with sesame oil, but not sesame seed, can ameliorate serum levels of lipids and hepatic enzymes in rabbits under a high-fat diet.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/365892