PROZ May Serve as a Prognostic Biomarker for Early Hepatocellular Carcinoma

Objective: The occurrence and development of hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate potential diagnostic or prognostic markers for early HCC by applying bioinformatic analysis. Methods: The gene expression profiles of early HCC and normal tissues from a TCGA d...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.4209-4218
Main Authors: Jiang, Xiaocong, Song, Ting, Pan, Xiuhua, Zhang, Xinyu, Lan, Yuhong, Bai, Li
Format: Article
Language:English
Subjects:
Apolipoproteins
bioinformatics analysis
Biomarkers
Biopsy
Datasets
Development and progression
Fibrin
Fibrinogen
Gene expression
Genes
Genomes
Glycoproteins
hepatocellular carcinoma
Hepatoma
Liver
Liver cancer
Medical prognosis
Metabolism
Ontology
Original Research
Proteins
Software
Survival analysis
vitamin k-dependent protein z
weighted gene coexpression network analysis
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Summary:Objective: The occurrence and development of hepatocellular carcinoma (HCC) remain unclear. This study aimed to investigate potential diagnostic or prognostic markers for early HCC by applying bioinformatic analysis. Methods: The gene expression profiles of early HCC and normal tissues from a TCGA dataset were used to identify differentially expressed genes (DEGs) and then analysed by weighted gene coexpression network analysis. The integrated genes were selected to construct the protein--protein interaction (PPI) network and determine the hub genes. The prognostic impact of the hub genes was then analysed. Results: A total of 508 integrated genes were selected from the 615 DEGs and 8956 genes in the turquoise module. A PPI network was constructed, and the top 20 hub genes, including apolipoprotein A-IV (APOA4), fibrinogen gamma chain (FGG), vitamin K-dependent protein Z (PROZ), secreted phosphoprotein 24 (SPP2) and fetuin-B (FETUB), were identified. Only PROZ was significantly associated with the prognosis of early HCC. Conclusion: In this study, we demonstrated that the expression of PROZ was decreased in early HCC compared with normal liver controls, and low PROZ expression might result in poor overall survival of early HCC. Keywords: hepatocellular carcinoma, weighted gene coexpression network analysis, bioinformatics analysis, vitamin K-dependent protein Z
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S311959