Tuberculosis arthritis of the sternoclavicular joint after uncomplicated falciparum malaria: a case report

• Published in: Annals of clinical microbiology and antimicrobials 2017-06, Vol.16 (1), p.44-44, Article 44
• Main Authors: Djiba, Boundia, Kane, Baidy Sy, Diallo, Mamadou Alpha, Diongue, Khadim, Diack, Ngoné Diaba, Deme, Hamidou, Dieng, Mouhamed, Sow, Maimouna, Ndiaye, Daouda, Pouye, Abdoulaye
• Format: Article
• Language: English
• Subjects: Anemia; Antimalarials - administration & dosage; Antitubercular Agents - administration & dosage; Arthritis; Arthritis - complications; Arthritis - drug therapy; Arthritis - microbiology; Arthritis - parasitology; Autoimmune hemolytic anemia; Bacilli; Blood; Care and treatment; Case Report; Case reports; Case studies; Co-infection; Complications and side effects; Density; Developing countries; Development and progression; Diagnosis; Diseases; Drugs; Family medical history; Female; Fever; Headache; Humans; Immunity; Infections; Infectious diseases; LDCs; Malaria; Malaria, Falciparum - complications; Malaria, Falciparum - parasitology; Medical imaging; Medicine; Mortality; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - isolation & purification; Mycobacterium tuberculosis - physiology; Parasites; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Plasmodium falciparum - isolation & purification; Prednisone; Prognosis; Risk factors; Smear; Sternoclavicular Joint - microbiology; Sternoclavicular Joint - parasitology; Swelling; Therapy; Trophozoites; Tuberculosis; Tuberculosis - complications; Tuberculosis - microbiology; Tuberculosis - parasitology; Vector-borne diseases; Young Adult
• ISSN: 1476-0711; 1476-0711
• DOI: 10.1186/s12941-017-0219-8

Malaria and tuberculosis are co-endemic in many developing countries. However their associations are rarely reported. Yet, it has been suggested that a pathological process may link the two diseases. A 20-year-old female patient was admitted in the internal medicine service of Aristide Le Dantec Hospital for uncomplicated malaria. She was previously treated for autoimmune hemolytic anaemia using prednisone at 5 mg per day. Clinical examination showed swelling in front of the sternoclavicular joint. She presented with fever and headache. Thick smear from blood revealed trophozoites of P. falciparum at parasite density of 52,300 parasites/μl. The Ziehl-Neelsen stained smear showed the presence of acid-fast bacilli from the fluid puncture of the swelling. Mycobacterium tuberculosis was further isolated in culture. The diagnosis of falciparum malaria co-infection with sternoclavicular tuberculosis was posed. The patient was treated successfully using antimalarial drugs subsequently followed by multidrug antitubercular therapy. Interactions between malaria and tuberculosis need to be largely and prospectively investigated and appropriate treatment should be undertaken.