Bioelectric Potential in Next-Generation Organoids: Electrical Stimulation to Enhance 3D Structures of the Central Nervous System

Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of developmental cues, including biochemical and biomechanica...

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Published in:Frontiers in cell and developmental biology 2022-05, Vol.10, p.901652-901652
Main Authors: O'Hara-Wright, Michelle, Mobini, Sahba, Gonzalez-Cordero, Anai
Format: Article
Language:English
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Summary:Pluripotent stem cell-derived organoid models of the central nervous system represent one of the most exciting areas in tissue engineering. Classically, organoids of the brain, retina and spinal cord have been generated via recapitulation of developmental cues, including biochemical and biomechanical. However, a lesser studied cue, bioelectricity, has been shown to regulate central nervous system development and function. In particular, electrical stimulation of neural cells has generated some important phenotypes relating to development and differentiation. Emerging techniques in bioengineering and biomaterials utilise electrical stimulation using conductive polymers. However, state-of-the-art pluripotent stem cell technology has not yet merged with this exciting area of bioelectricity. Here, we discuss recent findings in the field of bioelectricity relating to the central nervous system, possible mechanisms, and how electrical stimulation may be utilised as a novel technique to engineer "next-generation" organoids.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2022.901652