The gut microbiome changes in wild type and IL-18 knockout mice after 9.0 Gy total body irradiation

BACKGROUNDRecent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice, mini-pigs and nonhuman primates after radiation exposure. Blocking IL-18 using its endogenous binding protein (IL-18BP) increa...

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Bibliographic Details
Published in:Animal microbiome 2023-09, Vol.5 (1), p.42-42, Article 42
Main Authors: Cui, Wanchang, Hull, Lisa, Zizzo, Alex, Wang, Li, Lin, Bin, Zhai, Min, Xiao, Mang
Format: Article
Language:English
Subjects:
Gut microbiome
IL-18 knockout mice
Ionizing radiation
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Summary:BACKGROUNDRecent studies have shown that gut microbiome plays important roles in response to radiation exposure. IL-18, an inflammatory cytokine, is highly elevated in mice, mini-pigs and nonhuman primates after radiation exposure. Blocking IL-18 using its endogenous binding protein (IL-18BP) increases mice survival after radiation exposure by decreasing bone marrow interferon-gamma levels.METHODSTo further characterize the roles of IL-18 in response to radiation, both wild type and IL-18 knockout (IL-18 KO) mice were exposed to 9.0 Gy total body irradiation (TBI). The 30-day survival result demonstrated that IL-18 KO mice were significantly more resistant to radiation compared to the wild type mice (p 
ISSN:2524-4671
2524-4671
DOI:10.1186/s42523-023-00262-8