Impact of early caffeine administration on respiratory outcomes in very preterm infants initially receiving invasive mechanical ventilation

ObjectiveThe guidelines recommend early caffeine administration for preterm infants requiring non-invasive mechanical ventilation since earlier treatment is associated with better outcomes. The objective was to evaluate the impact of early caffeine therapy (within 24 hours after birth) on respirator...

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Published in:BMJ open respiratory research 2024-08, Vol.11 (1), p.e002285
Main Authors: Zhao, Yarui, Zhang, Lidan, Zhang, Mingtao, Li, Shuai, Sun, Xuemei, Sun, Xiaolin, Yao, Guo, Li, Cong, Li, Minmin, Song, Chunyu, He, Haiying, Jia, Yongfeng, Jv, Bing, Yu, Yonghui, Zhu, Yun, Wang, Li
Format: Article
Language:English
Subjects:
Apgar score
Birth weight
Bronchopulmonary Dysplasia - epidemiology
Bronchopulmonary Dysplasia - prevention & control
Caffeine
Caffeine - administration & dosage
Central Nervous System Stimulants - administration & dosage
Clinical medicine
Cohort analysis
Cohort Studies
Drug dosages
Drug induced Lung Disease
Extubation
Female
Gestational Age
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature
Lung diseases
Male
Newborn babies
Original Research
Paediatric Lung Disease
Premature babies
Premature birth
Prospective Studies
Pulmonary Disease, Chronic Obstructive
Respiration, Artificial
Respiratory Distress Syndrome, Newborn - therapy
Sepsis
Surfactants
Time Factors
Treatment Outcome
Ventilators
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Summary:ObjectiveThe guidelines recommend early caffeine administration for preterm infants requiring non-invasive mechanical ventilation since earlier treatment is associated with better outcomes. The objective was to evaluate the impact of early caffeine therapy (within 24 hours after birth) on respiratory outcomes in very preterm infants who were initially receiving invasive mechanical ventilation.MethodsThis was an observation cohort study from 1 January 2018 to 31 December 2022 based on a database that was prospectively collected and maintained. Infants who initially received invasive mechanical ventilation were divided into two groups based on the timing of caffeine initiation: within the first 24 hours after birth (early) and within 48 hours of birth or later (late). Generalised linear mixed models with a random effect model for the centre were used to assess the impact of different caffeine initiation times on neonatal outcomes.ResultsAmong the cohort of 9880 infants born at
ISSN:2052-4439
2052-4439
DOI:10.1136/bmjresp-2023-002285