Diet modifies the association between alcohol consumption and severe alcohol-related liver disease incidence

It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants. Alcoho...

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Bibliographic Details
Published in:Nature communications 2024-08, Vol.15 (1), p.6880-9, Article 6880
Main Authors: Petermann-Rocha, Fanny, Zhou, Ziyi, Mathers, John C., Celis-Morales, Carlos, Raubenheimer, David, Sattar, Naveed, Pell, Jill P., Forrest, Ewan, Ho, Frederick K.
Format: Article
Language:English
Subjects:
692/308/174
692/4020
692/499
692/699/1503/1607/1608
Adult
Aged
Alcohol
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcohol use
Alcohols
Diet
Diet - adverse effects
Female
Humanities and Social Sciences
Humans
Incidence
Liver
Liver diseases
Liver Diseases, Alcoholic - epidemiology
Liver Diseases, Alcoholic - etiology
Male
Middle Aged
multidisciplinary
Proportional Hazards Models
Prospective Studies
Risk analysis
Risk Factors
Science
Science (multidisciplinary)
Statistical models
United Kingdom - epidemiology
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Summary:It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. This study aimed to investigate if the association between alcohol consumption and severe ALD is modified by diet. This prospective study included 303,269 UK Biobank participants. Alcohol consumption and diet were self-reported. The diet score was created from 4 items selected using LASSO. Cox proportional hazard model showed that the diet score was monotonically associated with severe ALD risk, adjusted for sociodemographics, lifestyle factors, and alcohol consumption. Relative excess risk due to interaction analysis indicated that having a higher ALD diet score and a higher alcohol consumption simultaneously confers to 2.44 times (95% CI: 1.06-3.83) higher risk than the sum of excess risk of each factor. In this work, we show that people who have a poor diet might be more susceptible to severe ALD due to alcohol consumption. It is elusive why some heavy drinkers progress to severe alcohol-related liver disease (ALD) while others do not. Here we show that people who have a poor diet, as indicated with a data-driven score, might be more susceptible to severe ALD due to alcohol consumption.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-51314-9