Gut permeability and cognitive decline: A pilot investigation in the Northern Manhattan Study

Gut microbiota may impact cognitive function and decline, though data are limited. This pilot study examines the associations between gut dysbiosis products, plasma lipopolysaccharide (LPS) and soluble CD14 (sCD14), with cognitive decline and immune molecule activation among 40 participants in the l...

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Published in:Brain, behavior, & immunity. Health behavior, & immunity. Health, 2021-03, Vol.12, p.100214, Article 100214
Main Authors: Rundek, Tatjana, Roy, Sabita, Hornig, Mady, Cheung, Ying Kuen, Gardener, Hannah, DeRosa, Janet, Levin, Bonnie, Wright, Clinton B., Del Brutto, Victor J., Elkind, Mitchell SV, Sacco, Ralph L.
Format: Article
Language:English
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Short Communication
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Summary:Gut microbiota may impact cognitive function and decline, though data are limited. This pilot study examines the associations between gut dysbiosis products, plasma lipopolysaccharide (LPS) and soluble CD14 (sCD14), with cognitive decline and immune molecule activation among 40 participants in the longitudinal population-based Northern Manhattan Study. We selected stroke- and dementia-free participants at baseline with high activation levels of core components of the immune signaling pathways underlying microbiota metabolite-cognitive associations (IL-1, IL-17, TNF). Participants were followed with up to three complete neuropsychological assessments, at least 5 years apart. Elevated sCD14 was associated with high levels of IL-1 pathway activation (p ​
ISSN:2666-3546
2666-3546
DOI:10.1016/j.bbih.2021.100214