Gut mycobiome alterations and implications for liver diseases

Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfuncti...

Full description

Saved in:
Bibliographic Details
Published in:PLoS pathogens 2024-08, Vol.20 (8), p.e1012377
Main Authors: Zeng, Suling, Schnabl, Bernd
Format: Article
Language:English
Subjects:
Analysis
Animals
Antifungal agents
Biology and Life Sciences
Care and treatment
Composition
Diagnosis
Dosage and administration
Dysbiosis - microbiology
Fungi - pathogenicity
Gastrointestinal Microbiome - physiology
Humans
Liver diseases
Liver Diseases - microbiology
Medicine and Health Sciences
Microbiota (Symbiotic organisms)
Mycobiome
Review
Risk factors
RNA sequencing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c409t-95cdf531b1ee68b6da9963df7023e93b0f70eb86ebe3c58ca16f0a61bb6001203
container_end_page
container_issue 8
container_start_page e1012377
container_title PLoS pathogens
container_volume 20
creator Zeng, Suling
Schnabl, Bernd
description Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.
doi_str_mv 10.1371/journal.ppat.1012377
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_17a69db0e61446ee8a94b8908daa8395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A807061401</galeid><doaj_id>oai_doaj_org_article_17a69db0e61446ee8a94b8908daa8395</doaj_id><sourcerecordid>A807061401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-95cdf531b1ee68b6da9963df7023e93b0f70eb86ebe3c58ca16f0a61bb6001203</originalsourceid><addsrcrecordid>eNptkl-L1DAUxYso7rr6DUQKvujDjLmTNm0eRJZF14EFwT_P4Sa5HTO0zZiki_vtzTh12YLkIeHmdw73Xk5RvAS2Bt7Au72fwoj9-nDAtAYGG940j4pzqGu-anhTPX7wPiuexbhnrAIO4mlxxiWAYHJzXry_nlI53BmvnR-oxD5RwOT8GEscbemGQ-_MXOh8KHt3S6G0LhJGis-LJx32kV7M90Xx49PH71efVzdfrrdXlzcrUzGZVrI2tqs5aCASrRYWpRTcdg3bcJJcs_wi3QrSxE3dGgTRMRSgtWB5MMYviu3J13rcq0NwA4Y75dGpvwUfdgpDcqYnBQ0KaTUjAVUliFqUlW4lay1iy2WdvT6cvA6THsgaGlPAfmG6_BndT7XztwqAM1kzkR3ezA7B_5ooJjW4aKjvcSQ_RZUxJqsq7z2jr0_oDnNvbux8tjRHXF22rGG5SQaZWv-HysfS4IwfqXO5vhC8XQgyk-h32uEUo9p--7pkqxNrgo8xUHc_KjB1TJKak6SOSVJzkrLs1cM13Yv-RYf_Ac_6xmI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090944374</pqid></control><display><type>article</type><title>Gut mycobiome alterations and implications for liver diseases</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Zeng, Suling ; Schnabl, Bernd</creator><contributor>LeibundGut-Landmann, Salomé</contributor><creatorcontrib>Zeng, Suling ; Schnabl, Bernd ; LeibundGut-Landmann, Salomé</creatorcontrib><description>Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1012377</identifier><identifier>PMID: 39116092</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Antifungal agents ; Biology and Life Sciences ; Care and treatment ; Composition ; Diagnosis ; Dosage and administration ; Dysbiosis - microbiology ; Fungi - pathogenicity ; Gastrointestinal Microbiome - physiology ; Humans ; Liver diseases ; Liver Diseases - microbiology ; Medicine and Health Sciences ; Microbiota (Symbiotic organisms) ; Mycobiome ; Review ; Risk factors ; RNA sequencing</subject><ispartof>PLoS pathogens, 2024-08, Vol.20 (8), p.e1012377</ispartof><rights>Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.</rights><rights>COPYRIGHT 2024 Public Library of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c409t-95cdf531b1ee68b6da9963df7023e93b0f70eb86ebe3c58ca16f0a61bb6001203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309506/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309506/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39116092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>LeibundGut-Landmann, Salomé</contributor><creatorcontrib>Zeng, Suling</creatorcontrib><creatorcontrib>Schnabl, Bernd</creatorcontrib><title>Gut mycobiome alterations and implications for liver diseases</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.</description><subject>Analysis</subject><subject>Animals</subject><subject>Antifungal agents</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Composition</subject><subject>Diagnosis</subject><subject>Dosage and administration</subject><subject>Dysbiosis - microbiology</subject><subject>Fungi - pathogenicity</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Humans</subject><subject>Liver diseases</subject><subject>Liver Diseases - microbiology</subject><subject>Medicine and Health Sciences</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Mycobiome</subject><subject>Review</subject><subject>Risk factors</subject><subject>RNA sequencing</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkl-L1DAUxYso7rr6DUQKvujDjLmTNm0eRJZF14EFwT_P4Sa5HTO0zZiki_vtzTh12YLkIeHmdw73Xk5RvAS2Bt7Au72fwoj9-nDAtAYGG940j4pzqGu-anhTPX7wPiuexbhnrAIO4mlxxiWAYHJzXry_nlI53BmvnR-oxD5RwOT8GEscbemGQ-_MXOh8KHt3S6G0LhJGis-LJx32kV7M90Xx49PH71efVzdfrrdXlzcrUzGZVrI2tqs5aCASrRYWpRTcdg3bcJJcs_wi3QrSxE3dGgTRMRSgtWB5MMYviu3J13rcq0NwA4Y75dGpvwUfdgpDcqYnBQ0KaTUjAVUliFqUlW4lay1iy2WdvT6cvA6THsgaGlPAfmG6_BndT7XztwqAM1kzkR3ezA7B_5ooJjW4aKjvcSQ_RZUxJqsq7z2jr0_oDnNvbux8tjRHXF22rGG5SQaZWv-HysfS4IwfqXO5vhC8XQgyk-h32uEUo9p--7pkqxNrgo8xUHc_KjB1TJKak6SOSVJzkrLs1cM13Yv-RYf_Ac_6xmI</recordid><startdate>20240808</startdate><enddate>20240808</enddate><creator>Zeng, Suling</creator><creator>Schnabl, Bernd</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240808</creationdate><title>Gut mycobiome alterations and implications for liver diseases</title><author>Zeng, Suling ; Schnabl, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-95cdf531b1ee68b6da9963df7023e93b0f70eb86ebe3c58ca16f0a61bb6001203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Antifungal agents</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Composition</topic><topic>Diagnosis</topic><topic>Dosage and administration</topic><topic>Dysbiosis - microbiology</topic><topic>Fungi - pathogenicity</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Humans</topic><topic>Liver diseases</topic><topic>Liver Diseases - microbiology</topic><topic>Medicine and Health Sciences</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Mycobiome</topic><topic>Review</topic><topic>Risk factors</topic><topic>RNA sequencing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Suling</creatorcontrib><creatorcontrib>Schnabl, Bernd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Suling</au><au>Schnabl, Bernd</au><au>LeibundGut-Landmann, Salomé</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut mycobiome alterations and implications for liver diseases</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2024-08-08</date><risdate>2024</risdate><volume>20</volume><issue>8</issue><spage>e1012377</spage><pages>e1012377-</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>39116092</pmid><doi>10.1371/journal.ppat.1012377</doi><tpages>e1012377</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1553-7374
ispartof PLoS pathogens, 2024-08, Vol.20 (8), p.e1012377
issn 1553-7374
1553-7366
1553-7374
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_17a69db0e61446ee8a94b8908daa8395
source Open Access: PubMed Central; Publicly Available Content Database (Proquest) (PQ_SDU_P3)
subjects Analysis
Animals
Antifungal agents
Biology and Life Sciences
Care and treatment
Composition
Diagnosis
Dosage and administration
Dysbiosis - microbiology
Fungi - pathogenicity
Gastrointestinal Microbiome - physiology
Humans
Liver diseases
Liver Diseases - microbiology
Medicine and Health Sciences
Microbiota (Symbiotic organisms)
Mycobiome
Review
Risk factors
RNA sequencing
title Gut mycobiome alterations and implications for liver diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A22%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gut%20mycobiome%20alterations%20and%20implications%20for%20liver%20diseases&rft.jtitle=PLoS%20pathogens&rft.au=Zeng,%20Suling&rft.date=2024-08-08&rft.volume=20&rft.issue=8&rft.spage=e1012377&rft.pages=e1012377-&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1012377&rft_dat=%3Cgale_doaj_%3EA807061401%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c409t-95cdf531b1ee68b6da9963df7023e93b0f70eb86ebe3c58ca16f0a61bb6001203%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3090944374&rft_id=info:pmid/39116092&rft_galeid=A807061401&rfr_iscdi=true