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Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?
Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was...
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Published in: | Journal of functional biomaterials 2023-03, Vol.14 (3), p.173 |
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creator | Ranković, Maja Jevremović, Anka Janošević Ležaić, Aleksandra Arsenijević, Aleksandar Rupar, Jelena Dobričić, Vladimir Nedić Vasiljević, Bojana Gavrilov, Nemanja Bajuk-Bogdanović, Danica Milojević-Rakić, Maja |
description | Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18-21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes. |
doi_str_mv | 10.3390/jfb14030173 |
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FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18-21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.</description><identifier>ISSN: 2079-4983</identifier><identifier>EISSN: 2079-4983</identifier><identifier>DOI: 10.3390/jfb14030173</identifier><identifier>PMID: 36976097</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acridine ; acridine derivatives ; Adsorption ; anticancer ; Anticancer properties ; Antitumor agents ; Cancer ; Care and treatment ; Cell viability ; Colorectal cancer ; Colorectal carcinoma ; Colorimetry ; Crystal structure ; Cytotoxicity ; Drug delivery systems ; Drug dosages ; drug release ; Electron microscopy ; Fibroblasts ; Investigations ; Morphology ; Physiology ; Raman spectroscopy ; Solvation ; Surfactants ; Toxicity ; zeolite ; Zeolites</subject><ispartof>Journal of functional biomaterials, 2023-03, Vol.14 (3), p.173</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18-21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. 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spectroscopy</subject><subject>Solvation</subject><subject>Surfactants</subject><subject>Toxicity</subject><subject>zeolite</subject><subject>Zeolites</subject><issn>2079-4983</issn><issn>2079-4983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkstr3DAQh01paEKSU-_F0EuhONHTsk5hs30FAi00vfQi5PF4o8WWtpJd6H9fbTdNdksl0POb3zyYonhJyQXnmlyu-5YKwglV_FlxwojSldANf753Pi7OU1qTPGrSMCpeFMe81qomWp0U75bWl98xDG7C6uu82YQ4Ob8qFxBd5zym8jqENJV39-hiufCTA-sBY_kFYx_iuL1cnRVHvR0Snj_sp8W3D-_vlp-q288fb5aL2wqk4FMlJADtSIcdzUtLCGrVWmRtDrUHEA3DTjCwjFuOUrS2pj1vKEgJttNK8NPiZqfbBbs2m-hGG3-ZYJ358xDiytgcPgxoqAIOtOaMQCOkptq2Vmid3fca21Znraud1mZuR-wA_RTtcCB6-OPdvVmFn4YSImvWsKzw5kEhhh8zpsmMLgEOg_UY5mSY0kxSzgTN6Ot_0HWYo8-12lK0lk3DxBO1sjkD5_uQHcNW1CyUpFqpRteZuvgPlWeHo4PgsXf5_cDg7c4AYkgpYv-YJCVm20Rmr4ky_Wq_Lo_s35bhvwFeDsAr</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Ranković, 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Zeolite-Supporting Acridines Boost Their Anticancer Performance?</title><author>Ranković, Maja ; Jevremović, Anka ; Janošević Ležaić, Aleksandra ; Arsenijević, Aleksandar ; Rupar, Jelena ; Dobričić, Vladimir ; Nedić Vasiljević, Bojana ; Gavrilov, Nemanja ; Bajuk-Bogdanović, Danica ; Milojević-Rakić, Maja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-45cc1d0ded10deb00e97bae2b207fcc482ed42ca23a3e54ba61f381c55cad9743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acridine</topic><topic>acridine derivatives</topic><topic>Adsorption</topic><topic>anticancer</topic><topic>Anticancer properties</topic><topic>Antitumor agents</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cell viability</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorimetry</topic><topic>Crystal 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subjects | Acridine acridine derivatives Adsorption anticancer Anticancer properties Antitumor agents Cancer Care and treatment Cell viability Colorectal cancer Colorectal carcinoma Colorimetry Crystal structure Cytotoxicity Drug delivery systems Drug dosages drug release Electron microscopy Fibroblasts Investigations Morphology Physiology Raman spectroscopy Solvation Surfactants Toxicity zeolite Zeolites |
title | Can Zeolite-Supporting Acridines Boost Their Anticancer Performance? |
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