Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma

VAMP (Vesicle-associated membrane protein)-associated protein B and C (VAPB) has been widely studied in neurodegenerative diseases such as ALS, but little is known about its role in cancer. Medulloblastoma is a common brain malignancy in children and arises from undifferentiated cells during neurona...

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Bibliographic Details
Published in:Scientific reports 2023-11, Vol.13 (1), p.19481-19481, Article 19481
Main Authors: Faria Assoni, Amanda, Giove Mitsugi, Thiago, Wardenaar, René, Oliveira Ferreira, Raiane, Farias Jandrey, Elisa Helena, Machado Novaes, Gabriela, Fonseca de Oliveira Granha, Isabela, Bakker, Petra, Kaid, Carolini, Zatz, Mayana, Foijer, Floris, Keith Okamoto, Oswaldo
Format: Article
Language:English
Subjects:
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Amyotrophic lateral sclerosis
Antibodies
Brain cancer
Brain tumors
Breast cancer
Cell cycle
Cell proliferation
Genes
Genomes
Humanities and Social Sciences
Kinases
Medulloblastoma
Membrane proteins
multidisciplinary
Mutation
Neurodegeneration
Neurodegenerative diseases
Neurons
Patients
Pediatrics
Protein B
Proteins
Science
Science (multidisciplinary)
Software
Statistical analysis
Stem cells
Therapeutic targets
Tumorigenesis
Wnt protein
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Summary:VAMP (Vesicle-associated membrane protein)-associated protein B and C (VAPB) has been widely studied in neurodegenerative diseases such as ALS, but little is known about its role in cancer. Medulloblastoma is a common brain malignancy in children and arises from undifferentiated cells during neuronal development. Therefore, medulloblastoma is an interesting model to investigate the possible relationship between VAPB and tumorigenesis. Here we demonstrate that high VAPB expression in medulloblastoma correlates with decreased overall patient survival. Consistent with this clinical correlation, we find that VAPB is required for normal proliferation rates of medulloblastoma cells in vitro and in vivo. Knockout of VAPB (VAPB KO ) delayed cell cycle progression. Furthermore, transcript levels of WNT-related proteins were decreased in the VAPB KO . We conclude that VAPB is required for proliferation of medulloblastoma cells, thus revealing VAPB as a potential therapeutic target for medulloblastoma treatment.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-45319-5