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Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding -propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549,...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (11), p.3249 |
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| Main Authors: | , , , , , |
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| container_issue | 11 |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Luo, Han Lv, Yong-Feng Zhang, Hong Hu, Jiang-Miao Li, Hong-Mei Liu, Shou-Jin |
| description | A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding
-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds
and
exhibited significant cytotoxicity of all five cancer cell lines. |
| doi_str_mv | 10.3390/molecules26113249 |
| format | article |
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-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds
and
exhibited significant cytotoxicity of all five cancer cell lines.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules26113249</identifier><identifier>PMID: 34071319</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>A549 Cells ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Apoptosis ; Aqueous solutions ; Azide ; Azides - pharmacology ; Cell growth ; Cell Line, Tumor ; Chromatography ; Cycloaddition ; Cytotoxicity ; Drug Screening Assays, Antitumor ; Gene expression ; HL-60 Cells ; Humans ; Inhibitory Concentration 50 ; Kinases ; Liver cancer ; Magnetic Resonance Spectroscopy ; MCF-7 Cells ; Molecular Structure ; mollugin ; Pyrans - chemistry ; Solvents ; Structure-Activity Relationship ; synthesis ; Triazoles ; Triazoles - chemistry ; Tumor cell lines</subject><ispartof>Molecules (Basel, Switzerland), 2021-05, Vol.26 (11), p.3249</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-5f452e0f47944448038d61be74d17d9ecc7b88b97309049ad4108b7b2e5988493</citedby><cites>FETCH-LOGICAL-c493t-5f452e0f47944448038d61be74d17d9ecc7b88b97309049ad4108b7b2e5988493</cites><orcidid>0000-0002-9013-8489</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2539957194/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2539957194?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34071319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Han</creatorcontrib><creatorcontrib>Lv, Yong-Feng</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Hu, Jiang-Miao</creatorcontrib><creatorcontrib>Li, Hong-Mei</creatorcontrib><creatorcontrib>Liu, Shou-Jin</creatorcontrib><title>Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding
-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds
and
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Lv, Yong-Feng ; Zhang, Hong ; Hu, Jiang-Miao ; Li, Hong-Mei ; Liu, Shou-Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-5f452e0f47944448038d61be74d17d9ecc7b88b97309049ad4108b7b2e5988493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>A549 Cells</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Aqueous solutions</topic><topic>Azide</topic><topic>Azides - pharmacology</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Chromatography</topic><topic>Cycloaddition</topic><topic>Cytotoxicity</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Gene expression</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Inhibitory Concentration 50</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>MCF-7 Cells</topic><topic>Molecular Structure</topic><topic>mollugin</topic><topic>Pyrans - chemistry</topic><topic>Solvents</topic><topic>Structure-Activity Relationship</topic><topic>synthesis</topic><topic>Triazoles</topic><topic>Triazoles - chemistry</topic><topic>Tumor cell lines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Han</creatorcontrib><creatorcontrib>Lv, Yong-Feng</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Hu, Jiang-Miao</creatorcontrib><creatorcontrib>Li, Hong-Mei</creatorcontrib><creatorcontrib>Liu, Shou-Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Han</au><au>Lv, Yong-Feng</au><au>Zhang, Hong</au><au>Hu, Jiang-Miao</au><au>Li, Hong-Mei</au><au>Liu, Shou-Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2021-05-28</date><risdate>2021</risdate><volume>26</volume><issue>11</issue><spage>3249</spage><pages>3249-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding
-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds
and
exhibited significant cytotoxicity of all five cancer cell lines.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34071319</pmid><doi>10.3390/molecules26113249</doi><orcidid>https://orcid.org/0000-0002-9013-8489</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | A549 Cells Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Aqueous solutions Azide Azides - pharmacology Cell growth Cell Line, Tumor Chromatography Cycloaddition Cytotoxicity Drug Screening Assays, Antitumor Gene expression HL-60 Cells Humans Inhibitory Concentration 50 Kinases Liver cancer Magnetic Resonance Spectroscopy MCF-7 Cells Molecular Structure mollugin Pyrans - chemistry Solvents Structure-Activity Relationship synthesis Triazoles Triazoles - chemistry Tumor cell lines |
| title | Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives |
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