Effects of Portulaca oleracea (purslane) on liver function tests, metabolic profile, oxidative stress and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: a randomized, double-blind clinical trial

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. exhibits anti-oxidant, anti-inflammatory, and hepatoprotective effects. This clinical trial aimed to investigate the potential benefits of in improving NAFLD. This double-blind, randomized clinical trial enrolled 70 pati...

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Published in:Frontiers in nutrition (Lausanne) 2024-07, Vol.11, p.1371137
Main Authors: Milkarizi, Narges, Barghchi, Hanieh, Belyani, Saba, Bahari, Hossein, Rajabzade, Farnood, Ostad, Andisheh Norouzian, Goshayeshi, Ladan, Nematy, Mohsen, Askari, Vahid Reza
Format: Article
Language:English
Subjects:
inflammation
liver steatosis
non-alcoholic fatty liver
Nutrition
oxidative stress
Portulaca oleracea
purslane
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Summary:Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease. exhibits anti-oxidant, anti-inflammatory, and hepatoprotective effects. This clinical trial aimed to investigate the potential benefits of in improving NAFLD. This double-blind, randomized clinical trial enrolled 70 patients with NAFLD assigned to either the intervention group (  = 35) or placebo group (  = 35) using stratified block randomization. The intervention group received 700 mg supplement for eight weeks, while the control group received placebo capsules. In addition, all participants received a calorie-restricted diet. Liver steatosis and fibrosis were assessed using elastography along with liver function and metabolic tests, blood pressure measurements, body composition analysis and dietary records pre-and post-intervention. The average age of the participants was 44.01 ± 8.6 years, of which 34 (48.6%) were women. The group receiving showed significant weight changes, body mass index, fat mass index, and waist circumference compared to the placebo (  
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2024.1371137