Recent Advances in Managing Spinal Intervertebral Discs Degeneration

Low back pain (LBP) represents a frequent and debilitating condition affecting a large part of the global population and posing a worldwide health and economic burden. The major cause of LBP is intervertebral disc degeneration (IDD), a complex disease that can further aggravate and give rise to seve...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-06, Vol.23 (12), p.6460
Main Authors: Costăchescu, Bogdan, Niculescu, Adelina-Gabriela, Teleanu, Raluca Ioana, Iliescu, Bogdan Florin, Rădulescu, Marius, Grumezescu, Alexandru Mihai, Dabija, Marius Gabriel
Format: Article
Language:English
Subjects:
Apoptosis
Artificial Intelligence
artificial intervertebral discs
Back pain
Bioactive compounds
Biomarkers
Biomimetics
Calcification
Cell cycle
cell-based therapies
Collagen
Complications
Degeneration
Degenerative disc disease
Etiology
Exosomes
Growth factors
Humans
Inflammation
Intercellular Signaling Peptides and Proteins
Intervertebral Disc - pathology
intervertebral disc degeneration
Intervertebral Disc Degeneration - etiology
Intervertebral Disc Degeneration - pathology
Intervertebral Disc Degeneration - therapy
intervertebral disc repair
Intervertebral discs
Kinases
Low back pain
Low Back Pain - etiology
Low Back Pain - therapy
Melatonin
Pathogenesis
Postoperative
Regeneration
regeneration strategies
Review
Signal transduction
Signs and symptoms
Tumor necrosis factor-TNF
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Summary:Low back pain (LBP) represents a frequent and debilitating condition affecting a large part of the global population and posing a worldwide health and economic burden. The major cause of LBP is intervertebral disc degeneration (IDD), a complex disease that can further aggravate and give rise to severe spine problems. As most of the current treatments for IDD either only alleviate the associated symptoms or expose patients to the risk of intraoperative and postoperative complications, there is a pressing need to develop better therapeutic strategies. In this respect, the present paper first describes the pathogenesis and etiology of IDD to set the framework for what has to be combated to restore the normal state of intervertebral discs (IVDs), then further elaborates on the recent advances in managing IDD. Specifically, there are reviewed bioactive compounds and growth factors that have shown promising potential against underlying factors of IDD, cell-based therapies for IVD regeneration, biomimetic artificial IVDs, and several other emerging IDD therapeutic options (e.g., exosomes, RNA approaches, and artificial intelligence).
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23126460