Epidemiology and global spread of emerging tick-borne Alongshan virus

The emergence and spread of novel viral pathogens is a major threat to human health, particularly in the context of climate and human-induced change in land use. Alongshan virus (ALSV) is a tick-borne virus associated with human disease, which was first identified in northeast China. More recently,...

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Bibliographic Details
Published in:Emerging microbes & infections 2024-12, Vol.13 (1), p.2404271
Main Authors: Gömer, André, Lang, Arthur, Janshoff, Saskia, Steinmann, Joerg, Steinmann, Eike
Format: Article
Language:English
Subjects:
Alongshan virus
Arachnids
Arthropods
epidemiology
Genomes
one health
Pathogens
Review
segmented flavi-like viruses
ticks
urbanization
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Summary:The emergence and spread of novel viral pathogens is a major threat to human health, particularly in the context of climate and human-induced change in land use. Alongshan virus (ALSV) is a tick-borne virus associated with human disease, which was first identified in northeast China. More recently, several studies reported the emergence of ALSV in mammalian and arthropod hosts in multiple different countries outside of Asia, and the first viral genome sequencing data has become available. ALSV is a member of the Jingmenvirus group closely related to the family. Unusually, the positive-sense, single-stranded RNA genome of ASLV is segmented and consists of four distinct segments, two of which show homology with the NS3 and NS5 protein encoding regions of non-segmented flaviviruses. Transmission of arthropod-borne pathogens will likely increase in the future due to environmental change mediated by a variety of environmental and ecological factors and increasing human encroachment into wild animal habitats. In this review, we present current knowledge of global ALSV distribution and emergence patterns, highlight genetic diversity, evolution and susceptible species. Finally, we discuss the role of this emerging tick-borne virus in the context of urbanization and global health.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2024.2404271