Testicular volume in non‐obstructive azoospermia with a history of bilateral cryptorchidism may predict successful sperm retrieval by testicular sperm extraction

Purpose Cryptorchidism is one of the most common causes of non‐obstructive azoospermia (NOA) in adulthood. Even if early orchidopexy is performed to preserve fertility potential, some patients still suffer from azoospermia. Fertility potential is significantly lower in bilateral than unilateral cryp...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive medicine and biology 2020-10, Vol.19 (4), p.372-377
Main Authors: Osaka, Akiyoshi, Iwahata, Toshiyuki, Kobori, Yoshitomo, Shimomura, Yukihito, Yoshikawa, Naoki, Onota, Shin, Yamamoto, Atsushi, Ide, Hisamitsu, Sugimoto, Kouhei, Okada, Hiroshi
Format: Article
Language:English
Subjects:
Age
Analysis
Body mass index
Chemotherapy
Cryptorchidism
Cryptorchism
Fertility
Follicle-stimulating hormone
Glycoproteins
Infertility
Luteinizing hormone
Medical laboratories
microdissection testicular sperm extraction
Multivariate analysis
non‐obstructive azoospermia
orchidopexy
Original
Patients
Prognosis
Sperm
Spermatozoa
Surgeons
Testes
testicular volume
Testosterone
Y chromosomes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Cryptorchidism is one of the most common causes of non‐obstructive azoospermia (NOA) in adulthood. Even if early orchidopexy is performed to preserve fertility potential, some patients still suffer from azoospermia. Fertility potential is significantly lower in bilateral than unilateral cryptorchidism. The aims of this study were to identify clinical parameters that predict the likely success of sperm recovery by microscopic testicular sperm extraction (micro‐TESE) and also the likely outcome of intracytoplasmic sperm injection using sperm from NOA patients who submitted to bilateral orchidopexy. Methods Fifty‐two NOA patients with a history of bilateral cryptorchidism underwent micro‐TESE. The following clinical parameters were evaluated as predictive factors for successful sperm recovery: age at micro‐TESE; age at orchidopexy; period from orchidopexy to micro‐TESE; luteinizing hormone (LH); follicle‐stimulating hormone (FSH); testosterone; average testicular volume; and body mass index. Results In the successful sperm retrieval group, average testicular volume was significantly greater, while serum LH and FSH, and body mass index were significantly lower. In a multivariate analysis, average testicular volume was positively correlated with successful sperm recovery. Conclusion Our results indicate that testicular volume in NOA patients with bilateral cryptorchidism is a predictor for successful sperm recovery.
ISSN:1445-5781
1447-0578
DOI:10.1002/rmb2.12338