The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome

The components of metabolic syndrome (MetS) and hepatogastrointestinal diseases are widespread worldwide, since many factors associated with lifestyle and diet influence their development and correlation. Due to these growing health problems, it is necessary to search for effective alternatives for...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-07, Vol.23 (13), p.7229
Main Authors: Rodríguez-Pastén, Alicia, Pérez-Hernández, Nury, Añorve-Morga, Javier, Jiménez-Alvarado, Rubén, Cariño-Cortés, Raquel, Sosa-Lozada, Teresa, Fernández-Martínez, Eduardo
Format: Article
Language:English
Subjects:
Adjuvants
Antibiotics
Bacteria
Bile acids
Biotransformation
Carbohydrates
Cardiovascular disease
Chronic illnesses
Diabetes
Diet
Drugs
Dysbacteriosis
Enzymes
Gastrointestinal diseases
gut microbiota
Immune system
Immunomodulation
Inflammatory bowel disease
Lipid metabolism
Lipids
liver
Liver diseases
Metabolic disorders
Metabolic syndrome
Metabolites
Microbiota
Microorganisms
Obesity
Prebiotics
Probiotics
Review
Tumor necrosis factor-TNF
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Summary:The components of metabolic syndrome (MetS) and hepatogastrointestinal diseases are widespread worldwide, since many factors associated with lifestyle and diet influence their development and correlation. Due to these growing health problems, it is necessary to search for effective alternatives for prevention or adjuvants in treating them. The positive impact of regulated microbiota on health is known; however, states of dysbiosis are closely related to the development of the conditions mentioned above. Therefore, the role of prebiotics, probiotics, or symbiotic complexes has been extensively evaluated; the results are favorable, showing that they play a crucial role in the regulation of the immune system, the metabolism of carbohydrates and lipids, and the biotransformation of bile acids, as well as the modulation of their central receptors FXR and TGR-5, which also have essential immunomodulatory and metabolic activities. It has also been observed that they can benefit the host by displacing pathogenic species, improving the dysbiosis state in MetS. Current studies have reported that paraprobiotics (dead or inactive probiotics) or postbiotics (metabolites generated by active probiotics) also benefit hepatogastrointestinal health.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23137229