Mild aortic valve disease and the diastolic pressure–volume relationship in heart failure with preserved ejection fraction

ObjectiveMild aortic valve stenosis (AS) and aortic valve (AV) sclerosis are associated with diastolic dysfunction and increased mortality in the general population. This study specifically investigated the impact of mild AV disease in heart failure with preserved ejection fraction (HFpEF).MethodsCo...

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Bibliographic Details
Published in:Open heart 2021-10, Vol.8 (2), p.e001701
Main Authors: Verbrugge, Frederik H, Reddy, Yogesh N V, Eleid, Mackram F, Lin, Grace, Burkhoff, Daniel, Borlaug, Barry A
Format: Article
Language:English
Subjects:
Age
Aged
Aged, 80 and over
Aortic stenosis
Aortic Valve - surgery
aortic valve insufficiency
Aortic Valve Insufficiency - complications
Aortic Valve Insufficiency - physiopathology
Aortic Valve Insufficiency - surgery
aortic valve stenosis
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - physiopathology
Aortic Valve Stenosis - surgery
Blood pressure
Blood Pressure - physiology
Body mass index
Calcification
Cardiovascular disease
Diastole
diastolic
Echocardiography
Ejection fraction
Female
Follow-Up Studies
Health risk assessment
Heart failure
Heart Failure - diagnosis
Heart Failure - etiology
Heart Failure - physiopathology
Heart Failure and Cardiomyopathies
Heart Valve Prosthesis Implantation - methods
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Inflammation
Male
Mortality
Obesity
Patients
Peptides
Population
Retrospective Studies
Stroke
Stroke Volume - physiology
Ventricular Function, Left - physiology
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Summary:ObjectiveMild aortic valve stenosis (AS) and aortic valve (AV) sclerosis are associated with diastolic dysfunction and increased mortality in the general population. This study specifically investigated the impact of mild AV disease in heart failure with preserved ejection fraction (HFpEF).MethodsConsecutive patients hospitalised with HFpEF (n=370) underwent assessment of cardiac structure and function and long-term clinical follow-up.ResultsIn the study cohort, 111 had mild AS (30%), 104 AV sclerosis (28%) and 155 a non-calcified AV (42%). Mild-to-moderate AV regurgitation (AR) was present in 64 (17%). Compared with patients with a normal AV, those with AV disease were older, with worse renal function and more atrial fibrillation. E/e′ increased from non-calcified AV to AV sclerosis to mild AS (13.8 (10.8–16.8) vs 15.0 (10.9–20.0) vs 18.0 (12.7–23.3), respectively; p
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2021-001701