Liver function as a predictor of mortality in COVID-19: A retrospective study

• Published in: Annals of hepatology 2021-12, Vol.26, p.100553-100553, Article 100553
• Main Authors: Salık, Fikret, Uzundere, Osman, Bıçak, Mustafa, Akelma, Hakan, Akgündüz, Mesut, Korhan, Zeki, Kandemir, Deniz, Kaçar, Cem Kıvılcım
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biomarkers - blood; Coronavirus disease 2019; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 - mortality; Critical Illness; Critically ill patient; Female; Hospital Mortality; Humans; Intensive care unit; Intensive Care Units; Length of Stay; Liver - metabolism; Liver biochemical parameters abnormalities; Liver Diseases - blood; Liver Diseases - diagnosis; Liver Diseases - mortality; Liver Function Tests; Liver injury; Male; Middle Aged; Mortality; Original; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Turkey
• ISSN: 1665-2681; 2659-5982; 1665-2681
• DOI: 10.1016/j.aohep.2021.100553

In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time.