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Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication
Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in...
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| Published in: | Molecules (Basel, Switzerland) Switzerland), 2019-06, Vol.24 (12), p.2336 |
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| Main Authors: | , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c527t-70ba93947f594001eef4e343bc444c2e7cb9e6d01f6a2959912acae28aef41393 |
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| cites | cdi_FETCH-LOGICAL-c527t-70ba93947f594001eef4e343bc444c2e7cb9e6d01f6a2959912acae28aef41393 |
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| container_issue | 12 |
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| container_title | Molecules (Basel, Switzerland) |
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| creator | Remy, Simon Litaudon, Marc |
| description | Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; and their therapeutically relevant biological properties. Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure-activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed. |
| doi_str_mv | 10.3390/molecules24122336 |
| format | article |
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Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. The structure-activity relationships and the probable involvement of protein kinase C in their mechanism of action are also detailed.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules24122336</identifier><identifier>PMID: 31242603</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Activation ; Animals ; Antiviral activity ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biodiversity ; Chemical Sciences ; chikungunya ; Chikungunya Fever - drug therapy ; Chikungunya Fever - virology ; Chikungunya virus ; Chikungunya virus - drug effects ; Chikungunya virus - physiology ; Cytotoxicity ; daphnane ; Diterpenes ; Diterpenes - chemistry ; Diterpenes - pharmacology ; Drug development ; Epidemics ; Epithelial cells ; Euphorbiaceae ; Euphorbiaceae - chemistry ; flexibilane ; Flowers & plants ; HIV ; Human immunodeficiency virus ; Humans ; ingenane ; jatrophane ; Kinases ; Latent infection ; Molecular Structure ; phorbol ; PKC ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Platelet aggregation ; pre-myrsinane ; Protein kinase C ; Review ; Structure-Activity Relationship ; tigliane ; Tumors ; Vector-borne diseases ; Vero cells ; Virus Replication - drug effects ; Viruses</subject><ispartof>Molecules (Basel, Switzerland), 2019-06, Vol.24 (12), p.2336</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). 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Over the last decade many studies have reported the ability of macrocyclic diterpenoids to inhibit in cellulo the cytopathic effect induced by the chikungunya virus. This review; which covers the years 2011 to 2019; lists all macrocyclic diterpenoids that have been evaluated for their ability to inhibit viral replication. 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Litaudon, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-70ba93947f594001eef4e343bc444c2e7cb9e6d01f6a2959912acae28aef41393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Activation</topic><topic>Animals</topic><topic>Antiviral activity</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biodiversity</topic><topic>Chemical Sciences</topic><topic>chikungunya</topic><topic>Chikungunya Fever - drug therapy</topic><topic>Chikungunya Fever - virology</topic><topic>Chikungunya virus</topic><topic>Chikungunya virus - drug effects</topic><topic>Chikungunya virus - physiology</topic><topic>Cytotoxicity</topic><topic>daphnane</topic><topic>Diterpenes</topic><topic>Diterpenes - chemistry</topic><topic>Diterpenes - pharmacology</topic><topic>Drug development</topic><topic>Epidemics</topic><topic>Epithelial cells</topic><topic>Euphorbiaceae</topic><topic>Euphorbiaceae - chemistry</topic><topic>flexibilane</topic><topic>Flowers & plants</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>ingenane</topic><topic>jatrophane</topic><topic>Kinases</topic><topic>Latent infection</topic><topic>Molecular Structure</topic><topic>phorbol</topic><topic>PKC</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Platelet aggregation</topic><topic>pre-myrsinane</topic><topic>Protein kinase C</topic><topic>Review</topic><topic>Structure-Activity Relationship</topic><topic>tigliane</topic><topic>Tumors</topic><topic>Vector-borne diseases</topic><topic>Vero cells</topic><topic>Virus Replication - drug effects</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remy, Simon</creatorcontrib><creatorcontrib>Litaudon, Marc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remy, Simon</au><au>Litaudon, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2019-06-25</date><risdate>2019</risdate><volume>24</volume><issue>12</issue><spage>2336</spage><pages>2336-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of considerable interest due to their high structural diversity; 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| ispartof | Molecules (Basel, Switzerland), 2019-06, Vol.24 (12), p.2336 |
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| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Activation Animals Antiviral activity Antiviral Agents - chemistry Antiviral Agents - pharmacology Biodiversity Chemical Sciences chikungunya Chikungunya Fever - drug therapy Chikungunya Fever - virology Chikungunya virus Chikungunya virus - drug effects Chikungunya virus - physiology Cytotoxicity daphnane Diterpenes Diterpenes - chemistry Diterpenes - pharmacology Drug development Epidemics Epithelial cells Euphorbiaceae Euphorbiaceae - chemistry flexibilane Flowers & plants HIV Human immunodeficiency virus Humans ingenane jatrophane Kinases Latent infection Molecular Structure phorbol PKC Plant Extracts - chemistry Plant Extracts - pharmacology Platelet aggregation pre-myrsinane Protein kinase C Review Structure-Activity Relationship tigliane Tumors Vector-borne diseases Vero cells Virus Replication - drug effects Viruses |
| title | Macrocyclic Diterpenoids from Euphorbiaceae as A Source of Potent and Selective Inhibitors of Chikungunya Virus Replication |
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