Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD

• Published in: International journal of chronic obstructive pulmonary disease 2016-01, Vol.11 (1), p.1317-1326
• Main Authors: Kim, Eun Sun, Kim, Young Tae, Kang, Chang Hyun, Park, In Kyu, Bae, Won, Choi, Sun Mi, Lee, Jinwoo, Park, Young Sik, Lee, Chang-Hoon, Lee, Sang-Min, Yim, Jae-Joon, Kim, Young Whan, Han, Sung Koo, Yoo, Chul-Gyu
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Anesthesiology; Blood; Body mass index; Cancer patients; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - physiopathology; Carcinoma, Non-Small-Cell Lung - surgery; Chi-Square Distribution; Chronic obstructive pulmonary disease; Dyspnea; Dyspnea - epidemiology; Dyspnea - physiopathology; early COPD; Female; Forced Expiratory Volume; Health aspects; Hospital Mortality; Hospitals; Humans; Length of Stay; Logistic Models; Lung - physiopathology; Lung - surgery; Lung cancer; Lung cancer, Non-small cell; Lung diseases, Obstructive; Lung Neoplasms - diagnosis; Lung Neoplasms - mortality; Lung Neoplasms - physiopathology; Lung Neoplasms - surgery; Male; Middle Aged; Mortality; Multivariate Analysis; Odds Ratio; Original Research; Ostomy; Patients; Pneumonectomy - adverse effects; Pneumonectomy - mortality; Pneumonia; Postoperative Complications - diagnosis; Postoperative Complications - epidemiology; Postoperative Complications - mortality; Postoperative Complications - physiopathology; postoperative pulmonary complication; Prevalence; Prospective Studies; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - mortality; Pulmonary Disease, Chronic Obstructive - physiopathology; Quality of Life; Questionnaires; risk factor; Risk Factors; Seoul - epidemiology; Spirometry; Surveys and Questionnaires; Thoracic surgery; Time Factors; Treatment Outcome; Variables; Ventilators
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S105206

This study aimed to investigate whether the prevalence of postoperative pulmonary complications (PPCs) in patients with non-small-cell lung cancer (NSCLC) is even higher in the early stages of COPD than in such patients with normal lung function and to verify the usefulness of symptom- or quality of life (QoL)-based scores in predicting risk for PPCs. Patients undergoing pulmonary resection for NSCLC between July 2012 and October 2014 were prospectively enrolled. Preoperative measurements of lung function, dyspnea, and QoL, operative characteristics, PPCs, duration of postoperative hospitalization, and in-hospital mortality were assessed. Among 351 consecutive patients with NSCLC, 343 patients with forced expiratory volume in 1 second (FEV1) ≥70% of predicted value were enrolled. At least one PPC occurred in 57 (16.6%) patients. Prevalence of PPC was higher in patients with COPD (30.1%) than in those with normal spirometry (10.0%; P