Dual enzyme-powered chemotactic cross β amyloid based functional nanomotors

Nanomotor chassis constructed from biological precursors and powered by biocatalytic transformations can offer important applications in the future, specifically in emergent biomedical techniques. Herein, cross β amyloid peptide-based nanomotors (amylobots) were prepared from short amyloid peptides....

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2023-09, Vol.14 (1), p.5903-5903, Article 5903
Main Authors: Ghosh, Chandranath, Ghosh, Souvik, Chatterjee, Ayan, Bera, Palash, Mampallil, Dileep, Ghosh, Pushpita, Das, Dibyendu
Format: Article
Language:English
Subjects:
119/118
147/28
147/3
639/301/923/966
639/638/541/966
639/638/77/603
Catalysis
Cytochrome
Cytochrome c
Cytochromes
Enzymes
Humanities and Social Sciences
Motility
multidisciplinary
Nanotechnology devices
Navigation
Peptides
Precursors
Pyrogallol
Science
Science (multidisciplinary)
Substrates
Urea
Urease
β-Amyloid
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nanomotor chassis constructed from biological precursors and powered by biocatalytic transformations can offer important applications in the future, specifically in emergent biomedical techniques. Herein, cross β amyloid peptide-based nanomotors (amylobots) were prepared from short amyloid peptides. Owing to their remarkable binding capabilities, these soft constructs are able to host dedicated enzymes to catalyze orthogonal substrates for motility and navigation. Urease helps in powering the self-diffusiophoretic motion, while cytochrome C helps in providing navigation control. Supported by the simulation model, the design principle demonstrates the utilization of two distinct transport behaviours for two different types of enzymes, firstly enhanced diffusivity of urease with increasing fuel (urea) concentration and secondly, chemotactic motility of cytochrome C towards its substrate (pyrogallol). Dual catalytic engines allow the amylobots to be utilized for enhanced catalysis in organic solvent and can thus complement the technological applications of enzymes. Nanomotor chassis constructed from biological precursors and powered by biocatalytic transformations can offer important applications in the future. Here, the authors prepare short-peptide-based cross β amyloid nanomotors which can host dedicated enzymes with orthogonal substrates for motility and navigation.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-41301-x