Long-term machine perfusion of human split livers: a new model for regenerative and translational research

Recent advances in machine perfusion have revolutionised the field of transplantation by prolonging preservation, permitting evaluation of viability prior to implant and rescue of discarded organs. Long-term perfusion for days-to-weeks provides time to modify these organs prior to transplantation. B...

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Bibliographic Details
Published in:Nature communications 2024-11, Vol.15 (1), p.9809-10, Article 9809
Main Authors: Lau, Ngee-Soon, McCaughan, Geoffrey, Ly, Mark, Liu, Ken, Crawford, Michael, Pulitano, Carlo
Format: Article
Language:English
Subjects:
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Allografts
Cell therapy
Hepatocytes
Humanities and Social Sciences
Humans
Injury prevention
Liver
Liver Regeneration - physiology
Liver transplantation
Liver Transplantation - methods
multidisciplinary
Organ Preservation - instrumentation
Organ Preservation - methods
Organs
Perfusion
Perfusion - instrumentation
Perfusion - methods
Perspective
Science
Science (multidisciplinary)
Splitting
Stem cells
Translational Research, Biomedical - methods
Transplantation
Transplants
Transplants & implants
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Summary:Recent advances in machine perfusion have revolutionised the field of transplantation by prolonging preservation, permitting evaluation of viability prior to implant and rescue of discarded organs. Long-term perfusion for days-to-weeks provides time to modify these organs prior to transplantation. By using long-term normothermic machine perfusion to facilitate liver splitting and subsequent perfusion of both partial organs, possibilities even outside the clinical arena become possible. This model remains in its infancy but in the future, could allow for detailed study of liver injury and regeneration, and ex-situ treatment strategies such as defatting, genetic modulation and stem-cell therapies. Here we provide insight into this new model for research and highlight its great potential and current limitations. Long-term machine perfusion holds great promise in the field of liver transplantation, potentially allowing for extended viability checks as well as treatment of marginal discarded organs. Here, the authors discuss the advances in machine perfusion techniques for liver transplants as well as future potential clinical avenues that it will open up including potential splitting of livers.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-54024-4