Molecular insights into Sertoli cell function: how do metabolic disorders in childhood and adolescence affect spermatogonial fate?

Male infertility is a major public health concern globally with unknown etiology in approximately half of cases. The decline in total sperm count over the past four decades and the parallel increase in childhood obesity may suggest an association between these two conditions. Here, we review the mol...

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Bibliographic Details
Published in:Nature communications 2024-07, Vol.15 (1), p.5582-13, Article 5582
Main Authors: Cannarella, Rossella, Curto, Roberto, Condorelli, Rosita A., Lundy, Scott D., La Vignera, Sandro, Calogero, Aldo E.
Format: Article
Language:English
Subjects:
631/80/86
692/163/2743/1526
Adenosine
Adolescence
Adolescent
Adolescents
Animals
Apoptosis
Cell cycle
Child
Child development
Childhood
Children
Follicles
Gene expression
Humanities and Social Sciences
Humans
Infertility
Infertility, Male - metabolism
Insulin resistance
Insulin-like growth factors
Kinases
Male
Metabolic Diseases - metabolism
Metabolic disorders
Metabolism
Molecular modelling
multidisciplinary
Obesity
Overweight
Pediatric Obesity - metabolism
Pediatrics
Phosphorylation
Proteins
Puberty
Public health
Review
Review Article
Science
Science (multidisciplinary)
Sertoli Cells - metabolism
Sperm
Sperm Count
Spermatogenesis
Spermatogonia - metabolism
Substrates
Testes
Testis - growth & development
Testis - metabolism
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Summary:Male infertility is a major public health concern globally with unknown etiology in approximately half of cases. The decline in total sperm count over the past four decades and the parallel increase in childhood obesity may suggest an association between these two conditions. Here, we review the molecular mechanisms through which obesity during childhood and adolescence may impair future testicular function. Several mechanisms occurring in obesity can interfere with the delicate metabolic processes taking place at the testicular level during childhood and adolescence, providing the molecular substrate to hypothesize a causal relationship between childhood obesity and the risk of low sperm counts in adulthood. Pediatric obesity is increasing worldwide and its contribution to the decline is sperm count has been questioned. By comprehensively reviewing the literature, the authors herein report molecular mechanisms that may suggest the causality of this association.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-49765-1