Long noncoding RNA PVT1 promotes tumor growth and predicts poor prognosis in patients with diffuse large B‐cell lymphoma

• Published in: Cancer communications (London, England) England), 2020-10, Vol.40 (10), p.551-555
• Main Authors: Yang, Ruifeng, Shao, Tingting, Long, Manmei, Shi, Yongheng, Liu, Qiang, Yang, Linhua, Zhan, Ming
• Format: Article
• Language: English
• Subjects: Cancer; Cell cycle; Cell growth; Confidence intervals; Gene expression; Letter to the Editor; Letters to the Editor; Lymphatic system; Lymphoma; Medical prognosis; Survival analysis; Tumors
• ISSN: 2523-3548; 2523-3548
• DOI: 10.1002/cac2.12073

Thanks to large-scale gene expression profiling between DLBCL and normal B cells, vast groups of genes have been found deregulated. [...]various long non-coding RNAs (lncRNAs) have been reported aberrantly expressed in DLBCL [ 4, 5]. Multivariate Cox proportional hazards model showed that high PVT1 expression was associated with reduced PFS (relative risk [RR] = 1.85; 95% CI = 1.19-2.89; P = 0.006) and OS rates (RR = 1.91, 95% CI = 1.13-3.23; P = 0.015; Supplementary Table S2). [...]we analyzed the PFS and OS by combine PVT1 expression and national comprehensive cancer network international prognostic index (NCCN IPI) to assess the prognosis prediction ability. [...]reducing PVT1 expression by short hairpin RNA (shRNA) in both DB and OCI-Ly1 impeded tumor growth on mouse xenograft models, as shown by reduced tumor volume, tumor weight, and tumor formation rate (Figure 1F–I and Supplementary Figure S4). In the present study, we provided evidences that elevated PVT1 expression was found in DLBCL tissues compared with normal lymph node tissues, and was positively associated with adverse clinicopathological outcomes. [...]the PVT1 expression was also a potent independent poor prognostic factor in DLBCL.