Human urinary kallindinogenase therapy for acute ischemic stroke according to Chinese ischemic stroke subclassification: Clinical efficacy and risk factors

• Published in: Brain and behavior 2020-01, Vol.10 (1), p.e01461-n/a
• Main Authors: Chen, Si‐Qia, Mao, Dong‐Yang, Wei, Dun‐Can, He, Wen‐Zhen
• Format: Article
• Language: English
• Subjects: acute ischemic stroke; Aged; Atherosclerosis; Chinese ischemic stroke subclassification; Cholesterol; Classification; Etiology; Family medical history; FDA approval; Female; Homocysteine; human urinary kallidinogenase; Humans; Ischemic Stroke - drug therapy; Kallikreins - therapeutic use; large artery atherosclerosis; Male; Males; Middle Aged; Original Research; Retrospective Studies; risk factor; Risk Factors; Statistical analysis; Stroke; Treatment Outcome
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1461

Introduction To evaluate effectiveness of human urinary kallindinogenase (HUK) in patients with acute ischemic stroke (AIS) according to Chinese ischemic stroke subclassification (CISS) and analyzed risk factors of clinical efficacy. Methods In this retrospective study, 134 patients received conventional therapy were enrolled to control group, and 132 patients received HUK treatment were enrolled to HUK group. National Institute of Health Stroke Scale (NIHSS) score was used to evaluate the clinical efficacy. Multivariate analysis of risk factors was performed by using logistic regression. Results After treatment, NIHSS score of HUK group was significant lower than that of control group (p = .009). Effectiveness rate was 71.2% in HUK group, and 53.7% in control group, respectively (p = .003). The NIHSS of patients with large artery atherosclerosis (LAA) subtype in HUK group was significantly lower than that in control group (p = .005). The absence of HUK (OR = 2.75), homocysteine (OR = 0.15), and CS subtype (OR = 0.18) were risk factors for HUK clinical efficacy. Conclusions Human urinary kallindinogenase is an effective therapeutic approach for treatment of patients with AIS, especially in patients with LAA subtype. The absence of HUK, elevated homocysteine, and cardiogenic stroke subtype were risk factor for clinical efficacy of HUK. In this study, we aimed to evaluate the effectiveness of human urinary kallindinogenase (HUK) in patients with acute ischemic stroke (AIS) according to Chinese ischemic stroke subclassification and analyzed the risk factors of the clinical efficacy. We found that HUK is an effective therapeutic approach for the treatment of patients with AIS, especially in patients with large artery atherosclerosis subtype.