Second Near‐Infrared Activatable Nitric Oxide Releasing Nanoactuators for Photothermal Combinational Modulation of Epileptogenic Focus

Laser interstitial thermal therapy (LITT), which ablates diseased brain tissues via hyperthermia, has offered novel treatment approach for epilepsy; however, the current LITT protocols still lack ablation selectivity and disease‐modifying efficacy. A second near‐infrared (NIR‐II) activatable nitric...

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Bibliographic Details
Published in:Small structures 2024-05, Vol.5 (5), p.n/a
Main Authors: Liu, Jiansheng, Li, Jiajia, Shi, Yanhui, Zhu, Anni, Ding, Mengbin, Yu, Ningyue, Liu, Yongkang, Wang, Ping, Li, Jingchao, Liu, Yu
Format: Article
Language:English
Subjects:
Ablation
Epilepsy
Gold
Gold coatings
gold nanoparticles
Hyperthermia
In vivo methods and tests
laser interstitial thermal therapy
Modulation
Nanoparticles
Near infrared radiation
Nitric oxide
Photothermal conversion
Releasing
second near‐infrared
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Summary:Laser interstitial thermal therapy (LITT), which ablates diseased brain tissues via hyperthermia, has offered novel treatment approach for epilepsy; however, the current LITT protocols still lack ablation selectivity and disease‐modifying efficacy. A second near‐infrared (NIR‐II) activatable nitric oxide (NO) releasing nanoactuator is reported here for photothermal combinational modulation of epileptogenic focus. The nanoactuator is prepared by conjugating NO donor S‐nitrosoglutathione (GSNO) onto polydopamine‐coated gold (Au) nanoparticles (NPs), which shows excellent photothermal conversion capability and controlled NO‐releasing property upon illumination in the NIR‐II window. Both in vitro and in vivo study demonstrate that the nanoactuator could exert stronger cell killing effects as compared to its counterpart. Furthermore, the NIR‐II‐activated NO release could inhibit P‐gp expression by regulating NF‐κb pathway, resulting in reprogramming of epileptogenic microenvironment. This study thus offers a novel regulating strategy for the treatment of drug‐resistant epilepsy. A second near‐infrared (NIR‐II) activatable nitric oxide (NO) releasing nanoactuator is designed for modulating epileptogenic focus microenvironment. The nanoactuator exhibits strong photothermal conversion effect and photoinduced NO release to produce heat to kill abnormally discharging nerve cells in epileptogenic focus and downregulate P‐glycoprotein expression. A combination of brain ablation and P‐gp modulation in epileptogenic focus can reverse drug‐resistant epilepsy.
ISSN:2688-4062
2688-4062
DOI:10.1002/sstr.202300508